Bielicki D, Maciejewska E, Mietkiewski J, Peciłło A
Kliniki Gastroenterologii, Zakładu Patomorfologii PAM, Szczecinie.
Pol Tyg Lek. 1991;46(14-16):254-5.
In the last decade, the primary, biliary liver cirrhosis was diagnosed in 17 female patients aged between 33 and 72 years. The most frequent complaint were itching and jaundice. Hepatomegaly and itching predominated in the clinical signs Laboratory tests have shown and increase in alkaline phosphatase activity, gamma-glutamyltranspeptidase, and alanine-aminotransferase activities, accelerated ESR and decrease in blood serum albumins. Immunological abnormalities were found in 15 patients, including 12 with antimitochondrial antibodies. Liver biopsy was carried out in all patients enabling to diagnose the primary cirrhosis in 14 of them. Duration of the disease was between 1 and 9 years. Immunosuppressive treatment was carried out in 10 patients, and symptomatic treatment in the remaining 7 patients. No difference in the effect of therapy on actual health state of patients was seen.
在过去十年中，17名年龄在33至72岁之间的女性患者被诊断出患有原发性胆汁性肝硬化。最常见的症状是瘙痒和黄疸。临床体征以肝肿大和瘙痒为主。实验室检查显示碱性磷酸酶活性、γ-谷氨酰转肽酶和丙氨酸转氨酶活性升高，血沉加快，血清白蛋白降低。15名患者发现免疫异常，其中12名患者有抗线粒体抗体。所有患者均进行了肝活检，其中14名患者得以诊断为原发性肝硬化。病程为1至9年。10名患者接受了免疫抑制治疗，其余7名患者接受了对症治疗。治疗对患者实际健康状况的影响未见差异。
