Anway Matthew D, Skinner Michael K
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164-4231, USA.
Endocrinology. 2006 Jun;147(6 Suppl):S43-9. doi: 10.1210/en.2005-1058. Epub 2006 May 11.
Endocrine disruptors have recently been shown to promote an epigenetic transgenerational phenotype involving a number of disease states (e.g. male infertility). The anti-androgenic fungicide vinclozolin was found to act transiently at the time of embryonic sex determination to promote in the F1 generation a spermatogenic cell defect and subfertility in the male. When the animals were allowed to age up to 1 yr, a number of other disease states developed. This phenotype was transferred through the male germ line to all subsequent generations analyzed (F1-F4). The ability of an environmental factor (i.e. endocrine disruptor) to promote an epigenetic transgenerational phenotype impacts the potential hazards of environmental toxins, mechanisms of disease etiology, and evolutionary biology. The biological importance of the epigenetic actions of environmental agents is reviewed in the context of the primordial germ cell and development of epigenetic transgenerational phenotypes.
最近研究表明，内分泌干扰物会引发一种涉及多种疾病状态（如男性不育症）的表观遗传跨代表型。抗雄激素杀菌剂乙烯菌核利被发现，在胚胎性别决定时短暂起作用，从而在F1代雄性个体中引发精子发生细胞缺陷和生育力低下。当这些动物生长至1岁时，出现了许多其他疾病状态。这种表型通过雄性生殖系传递给所有后续分析的世代（F1 - F4）。环境因子（即内分泌干扰物）引发表观遗传跨代表型的能力，影响着环境毒素的潜在危害、疾病病因机制以及进化生物学。本文将在原始生殖细胞和表观遗传跨代表型发育的背景下，综述环境因子表观遗传作用的生物学重要性。
