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[红铅急性中毒时中枢神经系统的毒性损害]

[Toxic lesions to the central nervous system in acute poisoning with red lead].

作者信息

Pach J, Kuśmiderski J, Czeczótko B, Kamenczak A, Pokorska M

机构信息

Kliniki Toksykologii, Krakowie.

出版信息

Pol Tyg Lek. 1991;46(24-26):452-4.

PMID:1669089
Abstract

Three cases of poisoning with oral red lead are presented. All 3 young persons ingested red lead for suicidal purposes. Six months prior to this poisoning all of the underwent detailed, medical examinations which did not reveal any pathologies. Toxicological analysis of the body fluids has shown the following results of urinalysis: lead (Pb) 2.41-9.29 mg/L; delta-aminolevulinic acid (ALA) 1.7-2.7 mg%; coproporphyrin-0.033-0.11 mg/L. Central nervous system activity has been assessed with the aid of a complex psychiatric examination, psychological tests, EEG, and CT-scans of the head. Organic lesions to CNS have been diagnosed in all poisoned patients. All of them were re-examined 4 months and 3 years after poisoning. This has enabled dynamic evaluation of remote CNS damage.

摘要

本文报告了3例口服红丹中毒病例。所有3名年轻人均因自杀目的摄入红丹。在此次中毒事件发生前6个月,他们都接受了详细的医学检查,未发现任何病变。对体液进行的毒理学分析得出如下尿液分析结果:铅(Pb)2.41 - 9.29毫克/升;δ-氨基乙酰丙酸(ALA)1.7 - 2.7毫克%;粪卟啉 - 0.033 - 0.11毫克/升。借助综合精神检查、心理测试、脑电图和头部CT扫描对中枢神经系统活动进行了评估。所有中毒患者均被诊断出中枢神经系统存在器质性病变。在中毒后4个月和3年对他们全部进行了复查。这使得能够对中枢神经系统的远期损害进行动态评估。

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