Grodzińska L, Kostka-Trabka E, Basista M, Bieroń K, Sławiński M, Telesz E
Zakładu Farmakologii Klinicznej Katedry Farmakologii, Krakowie.
Pol Tyg Lek. 1991;46(32-34):598-600.
Twenty patients with obliterative atherosclerosis in the lower extremities arteries (Fontaine's stage II) were treated with nitrendipine (Bayotensin) given in the dose of 20 mg daily for 6 weeks. This therapy with nitrendipine produced improvement manifested by the prolongation of the distance of intermittent claudication, shortening of pain duration, increase in blood flow in the ischemic extremity, and increase in pressure index. At the same time, nitrendipine decreased ADP-produced platelet aggregation and activated fibrinolytic system. Clinical trials have shown that nitrendipine is effective in the obliterative atherosclerosis in the lower extremities.
二十名下肢动脉闭塞性动脉粥样硬化患者（Fontaine 分期 II 期）接受了尼群地平（拜心通）治疗，剂量为每日 20 毫克，持续 6 周。尼群地平治疗产生了改善效果，表现为间歇性跛行距离延长、疼痛持续时间缩短、缺血肢体血流量增加以及压力指数升高。同时，尼群地平降低了 ADP 诱导的血小板聚集并激活了纤溶系统。临床试验表明，尼群地平对下肢闭塞性动脉粥样硬化有效。
