Shiraishi Y
Humangenetik. 1975;27(1):31-44. doi: 10.1007/BF00283501.
Among 12 Itai-Itai disease patients examined, 8 patients showed a remarkably high frequency of chromatid aberrations, whereas the other 4 patients showed a much lower frequency of such aberrations, although a significant number of stable type aberrations was observed also in the latter patients. The frequencies of aneuploid cells of all 12 patients were significantly higher than those of the controls. The abnormalities were found in 50-hour and 72-hour cultures, from which it can be concluded that the aberrations occurred in the blood stem cell of the patients. In addition to these structural and numerical aberrations, satellite associations of the D and G group chromosomes were often observed.
在接受检查的12名痛痛病患者中，8名患者的染色单体畸变频率显著较高，而另外4名患者的此类畸变频率则低得多，尽管在后一组患者中也观察到了相当数量的稳定型畸变。所有12名患者的非整倍体细胞频率均显著高于对照组。在50小时和72小时培养物中发现了异常，由此可以得出结论，畸变发生在患者的血液干细胞中。除了这些结构和数量畸变外，还经常观察到D组和G组染色体的随体联合。
