[The immediate results of the combined chemotherapy of disseminated forms and recurrences of cervix uteri cancer with vincristine, platidiam and adriamycin].

Thirty patients with advanced or recurrent cervical cancer were given combination chemotherapy including 1 mg/m2 vincristine i. v. on days 1 and 8, 120 mg/m2 i. v. drop-wise on day 2 with hydration and forced diuresis and 40 mg/m2 adriamycin on day 9. Treatment courses were repeated every 3-4 weeks. Complete response was observed in 1 (3.3%) patient, while more than 50% regression of tumor was obtained in 12 (40%) patients raising the complete plus partial response rate to as high as 43.3%. Nausea and vomiting occurred in all the patients, myelosuppression--60%, nephrotoxic effect--44% and alopecia--in 96.7% of patients.