Ramírez-Herrera M A, Gabriel Ortíz G
Facultad de Ciencias Biológicas, Universidad de Guadalajara, Jalisco, México.
Arch Invest Med (Mex). 1990 Oct-Dec;21(4):293-8.
Fifty-four 15 day old male Wistar rats were given single intratesticular injection of experimental preparations which contained formaldehyde, xylocaine and epinephrine diluted in propylene glycol (FXEP); xylocaine in propylene glycol (XP): epinephrine in propylene glycol (EP) propylene glycol (P); formaldehyde in 0.1 M phosphate buffer solution (F); an one control group. The group of rats that were given FXEP underwent testicular weight reduction; body weight and size were not affected. Also the treatment with P produced atrophy and fibrosis in testis and a more severe testicular weight reduction. The sclerosing effect of P treatment was more satisfactory than treatment with FXEP, and apparently no one affected body weight and size, thus, this could be a safe, easy and inexpensive method for non surgical castration.
给54只15日龄雄性Wistar大鼠进行单次睾丸内注射实验制剂，这些制剂包含在丙二醇中稀释的甲醛、利多卡因和肾上腺素（FXEP）；丙二醇中的利多卡因（XP）；丙二醇中的肾上腺素（EP）；丙二醇（P）；0.1M磷酸盐缓冲溶液中的甲醛（F）；以及一个对照组。接受FXEP注射的大鼠组睾丸重量减轻；体重和体型未受影响。此外，用P处理导致睾丸萎缩和纤维化，且睾丸重量减轻更严重。P处理的硬化效果比FXEP处理更令人满意，而且显然对体重和体型没有影响，因此，这可能是一种安全、简便且廉价的非手术去势方法。
