Bieganowska M L, Głowniak K
Katedra Chemii Nieorganicznej i Analitycznej Akademii Medycznej, Lublinie.
Acta Pol Pharm. 1990;47(5-6):35-8.
The hydrophobic nature of drugs, very important feature in determination of biological activity, is in Hansch's approach characterized by the logarithm of partition coefficient (log P) determined in n-octanol -water system, or calculated from hydrophobic constants pi (Hansch) or f (Rekker). Those as well as other parameters of hydrophobicity (log k'w, RMw or chi-connectivity index) were correlated with the spasmolytic and cytostatic activity of some coumarins.
药物的疏水性是决定其生物活性的一个非常重要的特征。在汉施方法中，疏水性由正辛醇 - 水体系中测定的分配系数的对数（log P）来表征，或者由疏水性常数π（汉施）或f（雷克）计算得出。这些以及其他疏水性参数（log k'w、RMw或χ-连接性指数）与某些香豆素的解痉和细胞抑制活性相关。
