Yamada Y, Okamoto M, Kikuzaki H, Nakatani N
Department of Food Science and nutrition, Faculty of Human Life and Science, Doshisha Women's College, Kyoto, Japan.
Biosci Biotechnol Biochem. 1997 Apr;61(4):740-2. doi: 10.1271/bbb.61.740.
Seven coumaric compounds analogous to aurapten were synthesized. Their spasmolytic activity against Ba2+, acetylcholine and histamine was evaluated to investigate their structure-activity relationship. The results of the bioassay demonstrated the important roles of the cis type of double bond at C-2' and the epoxide between c-6' and 7'.
合成了七种与奥瑞普坦类似的香豆素化合物。评估了它们对钡离子、乙酰胆碱和组胺的解痉活性，以研究其构效关系。生物测定结果表明，C-2'位顺式双键和c-6'与7'之间的环氧化物起着重要作用。
