[研究体外培养的植物智利美登木组织中的细胞生长抑制剂。II. 尼泊尔美登木愈伤组织提取物的色谱分析]
[Investigating cytostatic substances in tissue of plants Maytenus Molina in in-vitro cultures. II. chromatographic test of extracts from callus of Maytenus wallichiana R. et B].
作者信息
Dymowski W, Furmanowa M
机构信息
Zakład Biologii i Botaniki Farmaceutycznej Instytutu Nauki o Leku Wydziału Farmaceutycznego Akademii Medycznej, Warszawie.
出版信息
Acta Pol Pharm. 1990;47(5-6):51-4.
PMID:1669332
Abstract
Maytenus wallichiana callus tissue was extracted. The extract was fractionated to achieve maytansine containing residue. In none of the fractions maytansine corresponding substance was found. However evaluation by Tetrahymena test indicated strong cytotoxicity (ID50 1.8 micrograms/cm3). Chromatography of biologically active fractions demonstrated the presence of colour chinone methide triterpenes (tingenone).
摘要
提取了沃氏美登木愈伤组织。提取物进行分馏以得到含美登素的残渣。在任何馏分中均未发现美登素相应物质。然而，通过四膜虫试验评估表明具有很强的细胞毒性（半数抑制浓度为1.8微克/立方厘米）。对生物活性馏分进行色谱分析表明存在有色的甲川醌三萜（tingenone）。
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