Colom L V, Bland B H
Department of Psychology, University of Calgary, Alberta, Canada.
Hippocampus. 1991 Jan;1(1):15-30. doi: 10.1002/hipo.450010104.
Simultaneously recorded pairs (from a single electrode) of cells in the medial septum (MS) vertical limb of the diagonal band of Broca (vDBB) were studied during the simultaneous occurrence of field activity in the hippocampal formation of urethane-anesthetized rats and following the systemic administration of atropine sulphate (ATSO4). The 2 types of field activities recorded were cholinergically mediated type 2 theta (theta) and large-amplitude irregular activity (LIA). The study had 3 objectives: (1) to determine if cells in close proximity in the MS/vDBB had a high probability of having similar discharge properties; (2) to determine the possible functional relationships occurring between pairs of MS/vDBB cells using standard cross correlational analyses; and (3) to determine the effects of ATSO4 on both the discharge properties of MS/vDBB cells and the interactions between these cells. Of the 143 cells recorded, 133 (93%) were theta-related and classified as theta-on or theta-off cells. theta-on cells had a significant increase in mean discharge rate during theta compared to their mean discharge rate during LIA and/or had a linear increase in discharge rate in relation to increases in theta frequency. theta-off cells had a significant increase in mean discharge rate during LIA compared to their mean discharge rate during theta and/or had a linear decrease in discharge rate in relation to increases in theta frequency. The remaining 10 (7%) cells were classified as nonrelated to theta. A probability analysis carried out on each of the separate criteria for classification revealed that several of these could predict whether or not cells were in close proximity of one another. Cells occurred in close proximity according to whether they had higher discharge rates during theta or LIA and according to whether or not they varied their discharge rates as theta frequency varied (linear-nonlinear). Cell discharge patterns of rhythmicity (phasic), or nonrhythmicity (tonic) on the other hand, were not good predictors of whether cells were in close proximity since there was an equal probability of a phasic cell being paired with either a phasic or a tonic cell. The presence of a phasic discharge pattern was, however, the main determinant of whether a correlation occurred between cell pairs. Cross correlations of the cell pair spike trains revealed that 50% of the 36 phasic-phasic cell pairs were correlated during both theta and LIA field activities. The characteristics of the cross correlation functions of these cell pairs (strong symmetrical correlations with sharp primary peaks or troughs occurring around the origin) suggested that they received shared excitatory and inhibitory inputs. The remaining 50% of the phasic-phasic pairs were cross correlated during theta only.(ABSTRACT TRUNCATED AT 400 WORDS)
在对乌拉坦麻醉大鼠海马结构进行场活动的同时，以及在全身给予硫酸阿托品（ATSO4）之后，对来自单一电极的内侧隔核（MS）和布罗卡斜角带垂直支（vDBB）中同时记录的细胞对进行了研究。记录的两种场活动类型分别是胆碱能介导的2型θ波（theta）和大振幅不规则活动（LIA）。该研究有三个目标：（1）确定MS/vDBB中紧邻的细胞是否很可能具有相似的放电特性；（2）使用标准交叉相关分析确定MS/vDBB细胞对之间可能发生的功能关系；（3）确定ATSO4对MS/vDBB细胞放电特性以及这些细胞之间相互作用的影响。在记录的143个细胞中，133个（93%）与theta相关，并被分类为theta开启或theta关闭细胞。theta开启细胞在theta期间的平均放电率相较于其在LIA期间的平均放电率有显著增加，和/或其放电率随theta频率增加呈线性增加。theta关闭细胞在LIA期间的平均放电率相较于其在theta期间的平均放电率有显著增加，和/或其放电率随theta频率增加呈线性下降。其余10个（7%）细胞被分类为与theta无关。对每个单独的分类标准进行的概率分析表明，其中几个标准可以预测细胞是否彼此紧邻。根据细胞在theta或LIA期间是否具有更高的放电率，以及根据它们是否随theta频率变化而改变放电率（线性 - 非线性），细胞会紧邻出现。另一方面，细胞节律性（相位性）或非节律性（紧张性）的放电模式并不是细胞是否紧邻的良好预测指标，因为相位性细胞与相位性或紧张性细胞配对的概率相等。然而，相位性放电模式的存在是细胞对之间是否发生相关性的主要决定因素。细胞对尖峰序列的交叉相关显示，在36对相位 - 相位细胞对中，50%在theta和LIA场活动期间都具有相关性。这些细胞对的交叉相关函数特征（在原点附近出现尖锐的主要峰值或波谷的强对称相关性）表明它们接受共享的兴奋性和抑制性输入。其余50%的相位 - 相位对仅在theta期间具有交叉相关性。（摘要截断于400字）
