Torres P, Guerra F, Daza J C, Miguel R, Moreno C, Sánchez Guijo P
General Pathology Department, Reina Sofía University Hospital, Córdoba, Spain.
J Investig Allergol Clin Immunol. 1991 Dec;1(6):395-403.
Although cell-mediated hypersensitivity seems to be the main immunological response of man in contact dermatitis, recent studies suggest the potential involvement of antibody-mediated and basophilic cutaneous hypersensitivity in the physiopathology of this affection. The aim of this work was to contribute data intended to clarify the possible involvement of factors traditionally assigned to humoral hypersensitivity in the pathology of contact dermatitis. For this purpose blood levels of the different immunoglobulins were determined in patients with contact dermatitis. Three phases were considered, namely, one in which the patients showed typical clinical signs (acute phase), another in which the lesions had subsided (intercrisis phase) and a third in which the signs had recurred (acute outbreak). All those patients who concomitantly suffered from or had any personal or family antecedents of type I hypersensitivity were excluded from the study. The results found were compared with those obtained for a control gorup consisting of healthy individuals with no atopic antecedents. No significant differences were found between the results obtained in the three phases. However, the IgE levels of the patients were significantly higher than those of the control group, whereas the differences in the IgE, IgA and IgM levels were insignificant.
尽管细胞介导的超敏反应似乎是人类接触性皮炎的主要免疫反应，但最近的研究表明，抗体介导的和嗜碱性皮肤超敏反应可能参与了这种疾病的病理生理过程。这项工作的目的是提供数据，以阐明传统上归因于体液超敏反应的因素在接触性皮炎病理中可能的参与情况。为此，测定了接触性皮炎患者血液中不同免疫球蛋白的水平。考虑了三个阶段，即患者表现出典型临床症状的阶段（急性期）、病变消退的阶段（发作间期）和症状复发的阶段（急性发作期）。所有同时患有I型超敏反应或有任何个人或家族I型超敏反应病史的患者均被排除在研究之外。将所得结果与由无特应性病史的健康个体组成的对照组的结果进行比较。在三个阶段获得的结果之间未发现显著差异。然而，患者的IgE水平显著高于对照组，而IgE、IgA和IgM水平的差异不显著。
