Torres P, Guerra F, Arenas A, Miguel R, Daza J C, Sánchez Guijo P
General Pathology Department, Reina Sofía University Hospital, Córdoba, Spain.
J Investig Allergol Clin Immunol. 1994 May-Jun;4(3):132-8.
Contact dermatitis is a delayed hypersensitivity reaction involving the skin as shock organ. In a delayed cutaneous hypersensitivity reaction to contact with an antigen, the afferent, central and efferent phases of the immune reaction remain untouched and the individual concerned has a nonspecific inflammatory response capacity. Hence, delayed cutaneous hypersensitivity tests and the dinitrochlorobenzene (DNCB) test are of great use in evaluating this type of reaction. This prompted us to evaluate the in vivo response of patients suffering from contact dermatitis, as studies on this topic have been focused on animal experimentation or in vitro techniques. We chose 30 patients with contact dermatitis and studied them at three different stages, namely, when the patients showed the typical clinical signs (acute phase), when the lesions had subsided (intercrisis phase) and when the signs had recurred (acute outbreak). We subjected them to delayed cutaneous hypersensitivity tests and the DNCB test. Both techniques revealed a decrease in the response in the intercrisis phase with respect to the other two phases and to a control group.
接触性皮炎是一种以皮肤作为休克器官的迟发型超敏反应。在对与抗原接触的迟发型皮肤超敏反应中，免疫反应的传入、中枢和传出阶段未受影响，相关个体具有非特异性炎症反应能力。因此，迟发型皮肤超敏试验和二硝基氯苯（DNCB）试验在评估此类反应中具有重要作用。这促使我们评估接触性皮炎患者的体内反应，因为关于这一主题的研究一直集中在动物实验或体外技术上。我们选择了30名接触性皮炎患者，并在三个不同阶段对他们进行研究，即患者表现出典型临床症状时（急性期）、皮损消退时（发作间期）以及症状复发时（急性发作期）。我们对他们进行了迟发型皮肤超敏试验和DNCB试验。两种技术均显示，与其他两个阶段以及对照组相比，发作间期的反应有所降低。
