Fry T L, Fried F A, Goven B A
Invest Urol. 1975 Jul;13(1):47-51.
Escherichia coli-induced renal ultrastructural changes were observed 4 hr after the intravenous injection of 2 times 10-minus 6 bacteria. The initial changes consisted of mitochondrial swelling followed by intracellular vacuolation, nuclear membrane dilation, and increased lysosomal phagocytic activity. Alterations in the appearance of proximal tubular lysosomes included a loss of osmiophilic staining properties. Many of the involved cells showed necrosis and can presumably act as a nidus for bacterial proliferation.
静脉注射2×10⁻⁶个细菌4小时后，观察到大肠杆菌引起的肾脏超微结构变化。最初的变化包括线粒体肿胀，随后出现细胞内空泡化、核膜扩张和溶酶体吞噬活性增加。近端肾小管溶酶体外观的改变包括嗜锇染色特性丧失。许多受累细胞显示坏死，可能成为细菌增殖的病灶。
