Podányi Beáta, Lengyel Gabriella, Kiss András, Szakonyi József, Schaff Zsuzsa, Fehér János
Multimedical Szakorvosi Rendelo.
Orv Hetil. 2006 Mar 26;147(12):547-50.
Relationship between hepatitis C virus (HCV) infection and lichen planus (LP) is well known but controversial in the literature.
Two patients with lichen planus and chronic hepatitis C are presented. One of them suffered with disseminated LP and the other had cutaneous and oral erosive symptoms.
The chronic hepatitis of the patients was proved by elevated ALT and AST level, anti HCV (ELISA) and HCV-PCR serological examinations and liver biopsy. The diagnosis of lichen planus established on he typical clinical symptoms and the histological examination.
HCV RNA in the skin specimen from the biopsy of the skin lesion was detected by RT-PCR method, but the non affected skin specimen from the first patient was HCV RNA negative. Treatment of the chronic hepatitis C with specific therapy (interferon-alpha + ribavirin) in the second patient led to the regression of lichen planus symptoms.
The authors supposed that the lichen planus is one of the extrahepatic manifestations of HCV infection and there is a real correlation between the two diseases in these cases.
丙型肝炎病毒（HCV）感染与扁平苔藓（LP）之间的关系已为人熟知，但在文献中存在争议。
报告两例扁平苔藓合并慢性丙型肝炎患者。其中一例为播散性扁平苔藓，另一例有皮肤和口腔糜烂症状。
通过谷丙转氨酶（ALT）和谷草转氨酶（AST）水平升高、抗HCV（酶联免疫吸附测定）和HCV - PCR血清学检查及肝活检证实患者患有慢性肝炎。根据典型临床症状和组织学检查确诊扁平苔藓。
采用逆转录 - 聚合酶链反应（RT - PCR）方法检测到第一例患者皮肤病变活检皮肤标本中的HCV RNA，但该患者未受累皮肤标本的HCV RNA为阴性。第二例患者采用特异性疗法（α干扰素 + 利巴韦林）治疗慢性丙型肝炎后，扁平苔藓症状消退。
作者推测扁平苔藓是HCV感染的肝外表现之一，在这些病例中这两种疾病之间存在实际关联。
