Dupond A S, Lacour J P, Lafont C, Ortonne J P
Service de Dermatologie, Hôpital Archet-2, Nice.
Ann Dermatol Venereol. 1998 Oct;125(10):676-8.
An increased prevalence of hepatitis C virus (HCV)-related hepatitis has been reported in patients with lichen planus. The aim of our retrospective study was to determine whether there is a relationship between the erosive form of oral lichen planus and HCV.
A retrospective study was conducted in a consecutive sample of 28 patients suffering from oral erosive lichen planus and seen in our department between 1992 and 1996. Anti-HCV antibodies were detected in all cases by third generation recombinant immunoblot assay. PCR was performed to detect HCV RNA in the serum sample from 19 patients.
Eight patients (29 p. 100) tested positive for HCV antibodies. These results were compared with the rate of HCV chronic carriers which is between 1 and 2 p. 100 in our region (Southern France). Among these 8 patients, 7 had severe chronic liver disease, and 5 of them were actively replicating the virus.
Our results suggest a strong relationship between erosive oral lichen planus and HCV-related chronic hepatitis. We conclude that patients with the erosive form of oral lichen planus should be systematically evaluated for HCV infection.
有报道称扁平苔藓患者中丙型肝炎病毒（HCV）相关性肝炎的患病率有所增加。我们这项回顾性研究的目的是确定口腔糜烂型扁平苔藓与HCV之间是否存在关联。
对1992年至1996年间在我们科室就诊的28例口腔糜烂型扁平苔藓患者的连续样本进行了一项回顾性研究。所有病例均通过第三代重组免疫印迹法检测抗HCV抗体。对19例患者的血清样本进行PCR检测以检测HCV RNA。
8例患者（29%）抗HCV抗体检测呈阳性。这些结果与我们所在地区（法国南部）HCV慢性携带者1%至2%的比例进行了比较。在这8例患者中，7例患有严重的慢性肝病，其中5例病毒正在活跃复制。
我们的结果表明口腔糜烂型扁平苔藓与HCV相关性慢性肝炎之间存在密切关联。我们得出结论，对于口腔糜烂型扁平苔藓患者，应系统评估其HCV感染情况。
