Uygun Sedat, Yanardag Halil, Karter Yesari, Demirci Sabriye
Department of Internal Medicine, Istanbul University, Cerrahpaşa Medical Faculty, Istanbul, Turkey.
Acta Medica (Hradec Kralove). 2006;49(1):51-7.
Clinical manifestations and prognosis of sarcoidosis are heterogenous and the prevalence varies depending on the country, area and race evaluated. Also the organs involved and courses of the disease differ greatly between countries, areas, races and individuals.
To investigate the sociodemographic characteristics, clinical presentation and symptoms and to determine the severity and prognosis of sarcoidosis in Turkey as a referral center.
Between January and July 2003 we retrospectively evaluated the outcome of the patients with sarcoidosis whose first clinical visits were between 1965 and 2003 in the multidisciplinary referral setting RS at Cerrahpasa Medical Faculty of the University of Istanbul. Data collected about each patient included sociodemographic characteristics, clinical presentation, symptoms, date of diagnosis, date and age of onset, method and stage of disease at the date of diagnosis and at the date of last evaluation; the mortality and survival rate were calculated. One hundred and sixty six consecutive patients whose first clinical visits were between 1965 and 2003 in the multidisciplinary RS at Cerrahpasa Medical Faculty were enrolled. We contacted every patient in our cohort by telephone calls or home visits. All those contacted were called back to outpatient clinic for a formal evaluation between June and September 2003. A formal physical examination and thorax radiography were performed in patients who came to the hospital. Their radiological stage, signs, symptoms and associated extrapulmonary manifestations were recorded.
At the initial presentation, the mean age of diagnosis was 40.3 years. The 31-40 age group is the group with the highest number of patients. Coughing was the most frequent symptom and erythema nodosum was the most frequent sign in both sexes. Thirty eight percent of patients had extrathoracic involvement. The most frequent extrapulmonary site of involvement was skin. The mortality rate was 11.6% (10.8% in females and 13% in males). Comorbidity was 3% (5 females, 1 male). Females, youngs and patients without extrathoracic involvement had higher survival rates.
Clinical characteristics, course and prognosis of sarcoidosis vary in different studies. The results may vary accordingly to ethnic, geographic, social and economic conditions.
结节病的临床表现和预后具有异质性，其患病率因所评估的国家、地区和种族而异。此外，不同国家、地区、种族和个体之间，受累器官和疾病进程也存在很大差异。
作为转诊中心，调查土耳其结节病患者的社会人口学特征、临床表现和症状，并确定疾病的严重程度和预后。
2003年1月至7月期间，我们回顾性评估了1965年至2003年期间在伊斯坦布尔大学切拉比帕萨医学院多学科转诊机构RS首次就诊的结节病患者的治疗结果。收集的每位患者的数据包括社会人口学特征、临床表现、症状、诊断日期、发病日期和年龄、诊断时及最后评估时的疾病方法和阶段；计算死亡率和生存率。纳入了1965年至2003年期间在切拉比帕萨医学院多学科RS首次就诊的166例连续患者。我们通过电话或家访联系了队列中的每位患者。2003年6月至9月期间，所有被联系者均被召回门诊进行正式评估。前来医院的患者进行了正式的体格检查和胸部X光检查。记录他们的放射学分期、体征、症状和相关的肺外表现。
初次就诊时，诊断的平均年龄为40.3岁。31 - 40岁年龄组患者数量最多。咳嗽是最常见的症状，结节性红斑是男女最常见的体征。38%的患者有胸外受累。最常见的肺外受累部位是皮肤。死亡率为11.6%（女性为10.8%，男性为13%）。合并症为3%（5名女性，1名男性）。女性、年轻人和无胸外受累的患者生存率较高。
不同研究中结节病的临床特征、病程和预后各不相同。结果可能因种族、地理、社会和经济状况而有所不同。
