Department of Pulmonary Diseases, Istanbul Medical Faculty, Istanbul University, Turkey.
Respirology. 2011 Apr;16(3):446-50. doi: 10.1111/j.1440-1843.2010.01878.x.
Extrapulmonary sarcoidosis is common, and is almost always associated with concomitant thoracic involvement. Extrapulmonary manifestations vary on the basis of gender, age at presentation and ethnicity. The aim of this study was to investigate extrapulmonary involvement in patients with sarcoidosis in Turkey.
This study was conducted by Turkish Thoracic Society Clinical Problems Study Group. New cases of sarcoidosis between 1 June 2004 and 31 May 2006 were recorded on electronic case record forms sent to all potential investigators and information about extrapulmonary involvement was collected.
One hundred and nineteen of 293 patients (83 female, 36 male, mean age = 45 ± 12 years) had extrapulmonary involvement in this study (40.6%). The median time to diagnosis was 6 months and this was longer than patients with just thoracic sarcoidosis (P = 0.001). Extrapulmonary symptoms were present in 181 (61.8%) patients, and skin lesions, arthralgia and back pain were the commonest (33.4%, 20.8% and 16.4%, respectively). Incidence of organ involvement was independent of age with the exception of ocular involvement, which was higher in those under the age of 40 years (P = 0.007).
Skin and peripheral lymph node involvement were the most common sites of extrapulmonary involvement and ocular involvement was more common in those under the age of 40 years in patients with sarcoidosis in a Turkish population.
肺外结节病很常见，几乎总是与同时存在的胸部受累有关。肺外表现根据性别、发病时的年龄和种族而有所不同。本研究的目的是调查土耳其结节病患者的肺外受累情况。
本研究由土耳其胸科学会临床问题研究小组进行。2004 年 6 月 1 日至 2006 年 5 月 31 日期间新诊断的结节病病例记录在电子病例记录表格上，并发送给所有潜在的研究者，收集有关肺外受累的信息。
在这项研究中，293 例患者中有 119 例（83 例女性，36 例男性，平均年龄 45 ± 12 岁）有肺外受累（40.6%）。中位诊断时间为 6 个月，长于仅有胸部结节病的患者（P = 0.001）。181 例（61.8%）患者出现肺外症状，皮肤病变、关节炎和背痛最为常见（分别为 33.4%、20.8%和 16.4%）。器官受累的发生率与年龄无关，但眼部受累除外，40 岁以下患者的眼部受累发生率较高（P = 0.007）。
在土耳其人群中，皮肤和外周淋巴结受累是肺外受累最常见的部位，眼部受累在 40 岁以下患者中更为常见。
