Lashner Bret A
Am J Gastroenterol. 2006 May;101(5):965-6. doi: 10.1111/j.1572-0241.2006.00513.x.
There are a growing number of reports comparing wireless capsule endoscopy (CE) to other diagnostic tests for use in patients with Crohn's disease. A meta-analysis of these studies in this issue of the Journal showed that the "diagnostic yield" of detecting lesions suggestive of active Crohn's disease is much higher with CE compared to other tests. Routine use of CE in Crohn's disease will increase true-positive testing, but also will increase the number of false-positive tests. Since the penalty of false-positive testing is very high (unnecessary use of toxic and expensive medications, and the stigma of being diagnosed with a serious chronic disease), CE should be used only in limited clinical situations. In particular, CE may be helpful in Crohn's disease patients without a stricture whose physician needs an added measure of certainty that active disease is present.
越来越多的报告将无线胶囊内镜检查（CE）与用于克罗恩病患者的其他诊断测试进行比较。本期《杂志》对这些研究的一项荟萃分析表明，与其他测试相比，CE检测提示活动性克罗恩病病变的“诊断率”要高得多。在克罗恩病中常规使用CE会增加真阳性检测，但也会增加假阳性检测的数量。由于假阳性检测的代价非常高（不必要地使用有毒且昂贵的药物，以及被诊断患有严重慢性疾病的污名），CE仅应在有限的临床情况下使用。特别是，CE可能对没有狭窄的克罗恩病患者有帮助，其医生需要进一步确定是否存在活动性疾病。
