Park Moo-In, Camilleri Michael
Department of Internal Medicine, College of Medicine, Kosin University, Busan, Korea.
Am J Gastroenterol. 2006 May;101(5):1129-39. doi: 10.1111/j.1572-0241.2006.00640.x.
Gastroparesis refers to chronically abnormal gastric motility characterized by symptoms suggestive of mechanical obstruction and delayed gastric emptying in the absence of mechanical obstruction. It may be idiopathic or attributable to neuropathic or myopathic abnormalities, such as diabetes mellitus, postvagotomy, postviral infection, and scleroderma. Dietary and behavioral modification, prokinetic drugs, and surgical interventions have been used in managing patients with gastroparesis. Although mild gastroparesis is usually well managed with these treatment options, severe gastroparesis may be very difficult to control and may require referral to a specialist center if symptoms are intractable despite pharmacological therapy and dietetic support. New advances in drug therapy, botulinum toxin injection, and gastric electrical stimulation techniques have been introduced and might provide new hope to patients with refractory gastroparesis. This article critically reviews the advances in the field from the perspective of the clinician.
胃轻瘫是指慢性异常胃动力，其特征为出现提示机械性梗阻的症状且在无机械性梗阻的情况下胃排空延迟。它可能是特发性的，也可能归因于神经性或肌病性异常，如糖尿病、迷走神经切断术后、病毒感染后以及硬皮病。饮食和行为调整、促动力药物以及手术干预已被用于管理胃轻瘫患者。尽管轻度胃轻瘫通常通过这些治疗方法能得到良好控制，但严重胃轻瘫可能极难控制，如果尽管有药物治疗和饮食支持但症状仍难以处理，则可能需要转诊至专科中心。药物治疗、肉毒杆菌毒素注射和胃电刺激技术方面的新进展已被引入，可能为难治性胃轻瘫患者带来新希望。本文从临床医生的角度对该领域的进展进行了批判性综述。
