Vega J A, Del Valle M E, Alvarez-Mendez J C, Hernandez L C, Zubizarreta J J, Calzada B
Departamento de Morfologia y Biologia Celular, Universidad de Oviedo, Spain.
Arch Anat Histol Embryol. 1990;73:59-66.
The cartilages of vestibulum nasi in rats of different ages (newborns, 1 week, 1 month and 12 months old) were studied immunohistochemically using monoclonal antibodies against glial fibrillary acidic protein (GFAP) and S-100 protein. The immunoreaction for both GFAP and S-100 protein results positive in a variable number of chondrocytes. The number of chondrocytes displaying GFAP-like immunoreaction does not change during development and maturation, whereas those showing S-100 protein-like immunoreactivity increase from birth to the adult state. The formation of cartilaginous tissue from neuroectodermic cells of neural crest has been postulated by several authors and our results strongly support these opinions; moreover, according to present findings S-100 protein could be involved in chondroid tissue formation.
使用抗胶质纤维酸性蛋白（GFAP）和S-100蛋白的单克隆抗体，对不同年龄（新生、1周、1个月和12个月大）大鼠的鼻前庭软骨进行免疫组织化学研究。GFAP和S-100蛋白的免疫反应在数量不等的软骨细胞中呈阳性。显示GFAP样免疫反应的软骨细胞数量在发育和成熟过程中没有变化，而显示S-100蛋白样免疫反应性的软骨细胞数量从出生到成年状态有所增加。几位作者推测神经嵴的神经外胚层细胞可形成软骨组织，我们的结果有力地支持了这些观点；此外，根据目前的研究结果，S-100蛋白可能参与软骨样组织的形成。
