Kepes J J, Perentes E
Department of Pathology and Oncology, University of Kansas, College of Health Sciences and Hospital, Kansas City 66103.
Anat Rec. 1988 Mar;220(3):296-9. doi: 10.1002/ar.1092200311.
Glial fibrillary acidic protein (GFAP), an intermediate filament, was first discovered in the cytoplasm of reactive astroglia and to this date is regarded as a rather characteristic component of both non-neoplastic and neoplastic astrocytes. It has, however, been found in other glial elements also, as well as in a few types of tissues outside the central nervous system. Chondrocytes in hyaline and fibrocartilage do not express GFAP, but in the elastic cartilage of the human epiglottis we found GFAP to be regularly present when tested with either polyclonal or monoclonal antibodies. While most types of cartilage in humans are believed to be of mesenchymal origin, embryologic relationship between epiglottal cartilage and the neural crest may play a role in the curious phenomenon of the regular presence of GFAP in the chondrocytes of the epiglottis.
胶质纤维酸性蛋白（GFAP）是一种中间丝，最初在反应性星形胶质细胞的细胞质中被发现，至今仍被视为非肿瘤性和肿瘤性星形胶质细胞的一种相当典型的成分。然而，在其他神经胶质成分中也发现了它，以及在中枢神经系统以外的少数几种组织中也有发现。透明软骨和纤维软骨中的软骨细胞不表达GFAP，但在用多克隆或单克隆抗体检测时，我们发现人会厌的弹性软骨中经常存在GFAP。虽然人类大多数类型的软骨被认为起源于间充质，但会厌软骨与神经嵴之间的胚胎学关系可能在会厌软骨细胞中经常出现GFAP这一奇特现象中起作用。
