Raj Ganesh V, Peterson Andrew C, Webster George D
Division of Urologic Surgery, Duke University Medical Center, Durham, North Carolina, USA.
J Urol. 2006 Jun;175(6):2186-90; discussion 2190. doi: 10.1016/S0022-5347(06)00307-7.
Artificial urinary sphincter urethral cuff erosion occurs in up to 5.0% of cases, presenting a complex management problem. We examine our experience with the eroded AUS, relating to preoperative risk factors, operative management and outcomes.
We reviewed the medical records of 637 patients undergoing bulbar urethral AUS implantation from 1990 to 2003 for demographic and surgical variables.
Of the 637 records reviewed, 46 patients underwent 54 explantations of the AUS device for erosions, including 13 who had the primary implant performed at our institution and 33 being referred for management of erosion after implantation elsewhere. Our institution erosion rate was 2.2%. Mean followup after AUS reimplant following erosion was 27.8 months (range 1 to 180). Comorbidities were more prevalent in patients with erosions included hypertension (p = 0.006), coronary artery disease (p = 0.03), prior radiation therapy (p = 0.006) and prior AUS revisions (p = 0.0001). A majority of patients had persistent mild incontinence (0 to 1 pad daily in 29 or 56.8%), moderate (1 to 3 pads daily in 9 or 17.4%) and severe (more than 3 pads daily in 6 or 11.8%) incontinence after secondary AUS implantation. Patients who underwent reimplantation after AUS cuff erosions have a significantly higher rate of second erosions (in 16, 34.8%) within an average of 6.7 months (range 3 to 24), including our own 11.8% institutional rate (in 4).
Our study suggests that patients with comorbidities including hypertension, coronary artery disease, prior radiation therapy and prior AUS revisions are more likely to have erosions of their AUS. Nevertheless, continence can still be salvaged using various strategies which optimize use of the remaining healthy urethral tissue.
人工尿道括约肌的尿道袖套侵蚀发生率高达5.0%,带来了复杂的处理难题。我们研究了侵蚀性人工尿道括约肌(AUS)的治疗经验,涉及术前危险因素、手术处理及治疗结果。
我们回顾了1990年至2003年间637例行球部尿道AUS植入术患者的病历,以获取人口统计学和手术变量信息。
在637份回顾的病历中,46例患者因侵蚀对AUS装置进行了54次取出术,其中13例在我院进行了初次植入,33例是在其他地方植入后因侵蚀转来我院处理。我院的侵蚀发生率为2.2%。侵蚀后再次植入AUS后的平均随访时间为27.8个月(范围1至180个月)。侵蚀患者的合并症更为常见,包括高血压(p = 0.006)、冠状动脉疾病(p = 0.03)、既往放疗史(p = 0.006)和既往AUS翻修史(p = 0.0001)。大多数患者在二次植入AUS后仍存在持续性轻度尿失禁(29例,占56.8%,每天使用0至1片尿垫)、中度尿失禁(9例,占17.4%,每天使用1至3片尿垫)和重度尿失禁(6例,占11.8%,每天使用超过3片尿垫)。AUS袖套侵蚀后接受再次植入的患者,在平均6.7个月(范围3至24个月)内发生二次侵蚀的比例显著更高(16例,占34.8%),其中我院的发生率为11.8%(4例)。
我们的研究表明,患有高血压、冠状动脉疾病、既往放疗史和既往AUS翻修史等合并症的患者更易发生AUS侵蚀。尽管如此,仍可采用各种策略挽救控尿功能,这些策略可优化对剩余健康尿道组织的利用。