Tookey P A, Jones G, Miller B H, Peckham C S
Epidemiology and Biostatistics Unit, Institute of Child Health, London.
CDR (Lond Engl Rev). 1991 Jul 19;1(8):R86-8.
Ninety-two pregnancies complicated by rubella vaccination were reported to the Rubella Vaccination in Pregnancy Study between 1981 and 1990. These pregnancies resulted in 87 live births, 3 stillbirths and two spontaneous abortions. One infant had serological evidence of congenital rubella infection but was healthy and normal with no indication of rubella damage at the age of two and half years. These findings suggest that the risk of rubella-associated damage following inadvertent rubella vaccination in pregnancy or shortly before is low, and support the current advice that termination of pregnancy should not be routinely recommended in these circumstances.
1981年至1990年间,“孕期风疹疫苗接种研究”共报告了92例因接种风疹疫苗而导致的妊娠病例。这些妊娠最终产下87名活婴、3例死产和2例自然流产。有一名婴儿有先天性风疹感染的血清学证据,但身体健康、发育正常,在两岁半时未表现出风疹损害迹象。这些研究结果表明,孕期或孕前意外接种风疹疫苗后出现风疹相关损害的风险较低,这也支持了目前的建议,即在这些情况下不应常规建议终止妊娠。