Gundogdu Sadi, Erdem C Zuhal, Erdem L Oktay, Bayar Ulku
Zonguldak Karaelmas University, School of Medicine, Department of Radiology, 67600 Kozlu/Zonguldak, Turkey.
Eur J Obstet Gynecol Reprod Biol. 2006 Nov;129(1):60-4. doi: 10.1016/j.ejogrb.2006.03.017. Epub 2006 May 15.
The objective was to determine the enhancement kinetics of the normal ovaries in healthy women on dynamic contrast-enhanced magnetic resonance (DCE-MR) imaging.
Twenty-one women who had normal ovulatory cycles (volunteers; mean age=26.3 years, range=20-35), normal hormone profile, and apparently normal ovaries on ultrasonographic scan underwent DCE-MR imaging on a 1.5-T system (Philips Medical Systems, Gyroscan Intera, Best, The Netherlands) using a phased array pelvic coil. Sequential images with an imaging time of 14.4s per dynamic image were acquired before and after injection of a contrast bolus at 30s and at 1, 2, 3, 4, and 5 min. On postprocessing examination the following measurements were obtained for ovarian and muscle tissue: the signal intensity value per dynamic study, early phase enhancement rate, time to peak enhancement (Tp), and percentage of wash-out at the fifth minute were determined. Data of the ovaries and skeletal muscle were compared using Wilcoxon's rank sum test.
Most of the mean values of the postcontrast signal intensity measurements, the mean values of the early phase enhancement rate, and the percentage of wash-out at the fifth minute were found to be significantly higher in ovary than in muscle (p<0.05). The mean values of Tp, on the other hand, were nonsignificantly lower in ovary than in muscle (p>0.05). On the examination of the mean signal intensity-time data graphics the ovary showed a tendency toward greater and quicker enhancement and wash-out.
In our opinion, DCE-MR imaging, which determines contrast enhancement such as wash-in and wash-out kinetics, can provide knowledge of ovarian vascularization. Thus, by using DCE-MR imaging, determination of these vascularization changes in various ovarian diseases may provide us with additional parameters in the diagnosis of and treatment strategies for ovarian diseases.
本研究旨在通过动态对比增强磁共振成像（DCE-MR）确定健康女性正常卵巢的强化动力学。
21名排卵周期正常（志愿者；平均年龄26.3岁，范围20 - 35岁）、激素水平正常且超声检查卵巢外观正常的女性，在1.5T系统（飞利浦医疗系统公司，Gyroscan Intera，荷兰贝斯特）上使用相控阵盆腔线圈进行DCE-MR成像。在注射对比剂团注前、30秒以及注射后1、2、3、4和5分钟时，采集每幅动态图像成像时间为14.4秒的序列图像。在图像后处理检查中，对卵巢和肌肉组织进行以下测量：每次动态研究的信号强度值、早期强化率、达到峰值强化的时间（Tp）以及第5分钟时的廓清百分比。使用Wilcoxon秩和检验比较卵巢和骨骼肌的数据。
发现对比剂注射后信号强度测量的大多数平均值、早期强化率的平均值以及第5分钟时的廓清百分比，卵巢均显著高于肌肉（p<0.05）。另一方面，卵巢的Tp平均值略低于肌肉，但差异无统计学意义（p>0.05）。在检查平均信号强度 - 时间数据图时，卵巢显示出更强且更快的强化和廓清趋势。
我们认为，DCE-MR成像可确定诸如流入和廓清动力学等对比增强情况，能提供有关卵巢血管化的信息。因此，通过使用DCE-MR成像，确定各种卵巢疾病中这些血管化变化，可为我们在卵巢疾病的诊断和治疗策略方面提供额外参数。
