Radford Alan D, Dawson Susan, Coyne Karen P, Porter Carol J, Gaskell Rosalind M
Department of Veterinary Clinical Science, University of Liverpool, Leahurst, Chester High Road, Neston, S. Wirral CH64 7TE, UK.
Vet Microbiol. 2006 Oct 5;117(1):14-8. doi: 10.1016/j.vetmic.2006.04.004. Epub 2006 Apr 18.
Feline calicivirus (FCV) has been shown to evolve within individual cats and in the environment of colonies. This evolution and the diversity it creates has important clinical implications, not only for the disease in cats, but also for attempts to control disease by vaccination. Generally speaking, existing vaccines appear to be very effective at controlling the majority of clinical disease. However, some concerns remain including a failure to induce sterilising immunity, occasional vaccine breakdowns, and for live vaccines, occasional vaccine-induced disease. Key areas for future vaccine development include monitoring and broadening the cross-reactivity of vaccine immunity to field viruses, especially the recently evolved highly virulent strains, and attempting to reduce/eliminate field virus shedding by vaccinated cats.
猫杯状病毒（FCV）已被证明可在个体猫体内以及猫群环境中发生进化。这种进化及其产生的多样性具有重要的临床意义，不仅关乎猫的疾病，也涉及通过接种疫苗控制疾病的尝试。一般而言，现有疫苗在控制大多数临床疾病方面似乎非常有效。然而，仍存在一些问题，包括无法诱导无菌免疫、偶尔出现疫苗失效情况，以及对于活疫苗，偶尔会引发疫苗诱导的疾病。未来疫苗开发的关键领域包括监测并拓宽疫苗免疫对野外病毒的交叉反应性，特别是最近进化出的高毒力毒株，并尝试减少/消除接种疫苗的猫排出野外病毒的情况。
