Portillo Patricia M, Muzzio Fernando J, Ierapetritou Marianthi G
Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ 08854, USA.
Int J Pharm. 2006 Aug 31;320(1-2):14-22. doi: 10.1016/j.ijpharm.2006.03.051. Epub 2006 Apr 18.
Powder mixing has been the subject of substantial research due to its importance in a variety of industrial sectors, including pharmaceuticals, food, and polymer manufacturing. Although a number of different models have been proposed in the literature, most of them are either empirical or require computationally intensive calculations that make them difficult to implement for realistic systems. The aim of this paper is to develop a simplified framework, based on compartment modeling that efficiently and accurately captures the system behavior. Using the V-blender as a model system, the compartment modeling approach was used to illustrate the effects of vessel loading on mixing as well as the impact of sampling methods on the accuracy of mixing characterization.
由于粉末混合在包括制药、食品和聚合物制造在内的各种工业领域中的重要性，它一直是大量研究的主题。尽管文献中已经提出了许多不同的模型，但大多数模型要么是经验性的，要么需要大量的计算，这使得它们难以应用于实际系统。本文的目的是基于隔室建模开发一个简化框架，该框架能够高效、准确地捕捉系统行为。以V型混合器作为模型系统，采用隔室建模方法来说明容器装载量对混合的影响以及采样方法对混合特性表征准确性的影响。
