Hoogerwerf Willemijntje A, Sarna Sushil K
Department of Internal Medicine, Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, The University of Texas Medical Branch, Galveston, TX 77555-1064, USA.
Dig Dis. 2006;24(1-2):83-90. doi: 10.1159/000090311.
The tachykinins and their receptors are strategically distributed within the gut wall, spinal cord, and central nervous system to be potential targets of therapeutic agents for gastrointestinal motility disorders. However, the development of effective tachykinin receptor agonists or antagonists to treat these disorders has had very limited success so far. This is, in part, due to the complex and multilevel of regulation of gastrointestinal motility function and the challenges faced in targeting the specific type of gut contraction to normalize function in disease state.
速激肽及其受体在肠壁、脊髓和中枢神经系统中呈策略性分布，有望成为治疗胃肠动力障碍药物的潜在靶点。然而，迄今为止，开发有效的速激肽受体激动剂或拮抗剂来治疗这些疾病的成效非常有限。部分原因在于胃肠动力功能的调节复杂且具有多层次性，以及在针对特定类型的肠道收缩以恢复疾病状态下的正常功能时所面临的挑战。
