Oliveira Jacqueline Ferreira de, Greco Dirceu Bartolomeu, Oliveira Guilherme Correa, Christo Paulo Pereira, Guimarães Mark Drew Crosland, Oliveira Rodrigo Corrêa
Minas Gerais Hospital State Foundation, Hospital Eduardo de Menezes, Belo Horizonte, MG, Brazil.
Rev Soc Bras Med Trop. 2006 Mar-Apr;39(2):146-51. doi: 10.1590/s0037-86822006000200002. Epub 2006 May 5.
To study characteristics of neurological disorders in HIV/AIDS patients and their relationship to highly active antiretroviral treatment, a cross-sectional study was conducted in an infectious disease public hospital in Belo Horizonte, Brazil, between February 1999 and March 2000. Of the 417 patients enrolled, neurological disease was observed in 194 (46.5%) and a new AIDS-defining neurological event developed in 23.7% of individuals. Toxoplasmosis (42.3%), cryptococcosis meningitis (12.9%) and tuberculosis (10.8%) were the most common causes of neurological complications. The majority (79.3%) of patients were on highly active antiretroviral treatment and these individuals using HAART showed higher CD4 cell counts (p = 0.014) and presented stable neurological disease (p = 0.0001), although no difference was found with respect to the profile of neurological complications. The neurological diseases continue to be a frequent complication of HIV/AIDS and infections are still its main causes in Brazil, even in the highly active antiretroviral treatment era.
为研究艾滋病病毒/艾滋病（HIV/AIDS）患者的神经障碍特征及其与高效抗逆转录病毒治疗的关系，于1999年2月至2000年3月在巴西贝洛奥里藏特的一家传染病公立医院开展了一项横断面研究。在纳入研究的417例患者中，194例（46.5%）观察到神经疾病，23.7%的个体出现了一种新的艾滋病界定神经事件。弓形虫病（42.3%）、隐球菌性脑膜炎（12.9%）和结核病（10.8%）是神经并发症的最常见原因。大多数（79.3%）患者接受高效抗逆转录病毒治疗，使用高效抗逆转录病毒疗法（HAART）的这些个体CD4细胞计数较高（p = 0.014）且神经疾病稳定（p = 0.0001），尽管在神经并发症谱方面未发现差异。在巴西，即使在高效抗逆转录病毒治疗时代，神经疾病仍是HIV/AIDS的常见并发症，感染仍是其主要病因。
