毛果芸香碱用于治疗甲状腺癌放射性碘治疗引起的唾液腺损伤。
Pilocarpine for the treatment of salivary glands' impairment caused by radioiodine therapy for thyroid cancer.
作者信息
Aframian D J, Helcer M, Livni D, Markitziu A
机构信息
Salivary Gland Clinic, Department of Oral Medicine, The Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel.
出版信息
Oral Dis. 2006 May;12(3):297-300. doi: 10.1111/j.1601-0825.2005.01195.x.
OBJECTIVES
To study the effect of single-dose pilocarpine hydrochloride 5 mg on the whole unstimulated and stimulated salivary flow in patients suffering from thyroid cancer treated with radioiodine therapy, and to investigate the changes in vital signs during the treatment.
SUBJECTS AND METHODS
Five such patients were referred with complaints of dry mouth, rampant caries, and pain in the parotid gland region or history of chronic recurrent suppurative sialodenitis. A single dose of 5 mg pilocarpine hydrochloride was administered to each patient and blood pressure, heart rate, body temperature and salivary secretion rate were monitored at 1, 2 and 3 h.
RESULTS
A significant elevation of unstimulated and stimulated saliva flow rate was observed in four patients without significant alteration of the monitored vital signs.
CONCLUSIONS
Treatment with pilocarpine hydrochloride may be beneficial in the case of impaired salivary function in patients treated with radioiodine.
目的
研究单剂量5毫克盐酸毛果芸香碱对接受放射性碘治疗的甲状腺癌患者未刺激和刺激后的全唾液流量的影响，并调查治疗期间生命体征的变化。
受试者与方法
五名此类患者因口干、猖獗性龋齿、腮腺区疼痛或慢性复发性化脓性涎腺炎病史前来就诊。给每位患者单次服用5毫克盐酸毛果芸香碱，并在1、2和3小时监测血压、心率、体温和唾液分泌率。
结果
在四名患者中观察到未刺激和刺激后的唾液流速显著升高，而监测的生命体征无明显变化。
结论
对于接受放射性碘治疗的患者唾液功能受损的情况，使用盐酸毛果芸香碱治疗可能有益。
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