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头颈部癌放射治疗常见的口腔并发症:黏膜炎、感染、唾液改变、纤维化、感觉功能障碍、龋齿、牙周疾病和放射性骨坏死。

Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis.

作者信息

Sroussi Herve Y, Epstein Joel B, Bensadoun Rene-Jean, Saunders Deborah P, Lalla Rajesh V, Migliorati Cesar A, Heaivilin Natalie, Zumsteg Zachary S

机构信息

Division of Oral Medicine & Dentistry, Brigham and Women's Hospital, Boston, MA.

Samuel Oschin Comprehensive Cancer Instititue, Cedars-Sinai Medical Center, Los Angeles, CA.

出版信息

Cancer Med. 2017 Dec;6(12):2918-2931. doi: 10.1002/cam4.1221. Epub 2017 Oct 25.

Abstract

Patients undergoing radiation therapy for the head and neck are susceptible to a significant and often abrupt deterioration in their oral health. The oral morbidities of radiation therapy include but are not limited to an increased susceptibility to dental caries and periodontal disease. They also include profound and often permanent functional and sensory changes involving the oral soft tissue. These changes range from oral mucositis experienced during and soon after treatment, mucosal opportunistic infections, neurosensory disorders, and tissue fibrosis. Many of the oral soft tissue changes following radiation therapy are difficult challenges to the patients and their caregivers and require life-long strategies to alleviate their deleterious effect on basic life functions and on the quality of life. We discuss the presentation, prognosis, and management strategies of the dental structure and oral soft tissue morbidities resulting from the administration of therapeutic radiation in head and neck patient. A case for a collaborative and integrated multidisciplinary approach to the management of these patients is made, with specific recommendation to include knowledgeable and experienced oral health care professionals in the treatment team.

摘要

接受头颈部放射治疗的患者口腔健康极易出现显著且往往突然的恶化。放射治疗的口腔并发症包括但不限于龋齿和牙周病易感性增加。还包括涉及口腔软组织的严重且往往是永久性的功能和感觉变化。这些变化范围从治疗期间及治疗后不久出现的口腔黏膜炎、黏膜机会性感染、神经感觉障碍和组织纤维化。放射治疗后许多口腔软组织变化对患者及其护理人员来说都是艰巨挑战,需要终身策略来减轻其对基本生活功能和生活质量的有害影响。我们讨论了头颈部患者接受治疗性放射后牙齿结构和口腔软组织并发症的表现、预后及管理策略。提出了采用协作性和综合性多学科方法管理这些患者的理由,并特别建议在治疗团队中纳入知识渊博且经验丰富的口腔保健专业人员。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9cf/5727249/be142dd6efeb/CAM4-6-2918-g001.jpg

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