Zhang Xiao-Jun, Heggers John P, Chinkes David L, Wolf Steven E, Hawkins Hal K, Wolfe Robert R
Metabolism Unit, University of Texas Medical Branch, Galveston, TX, USA.
Surgery. 2006 May;139(5):633-9. doi: 10.1016/j.surg.2005.10.013.
Whereas Sulfamylon is effective in treatment of burn wound infection, controversy exists regarding its effect on the healing process.
A partial thickness skin donor site wound was created on the back and indwelling catheters were placed in the carotid artery and jugular vein in rabbits under general anesthesia. Sulfamylon cream (8.5%, BERTEK Pharmaceuticals Inc., Morgantown, W Va) was applied on the wound, with either open or occlusive dressing. The control wound was covered with dressings only. On day 7 after injury, stable isotope tracers were infused to determine the fractional synthetic rate (FSR) of DNA, and FSR and fractional breakdown rate (FBR) of protein in the wound.
In the Sulfamylon-open dressing group, the DNA FSR was 1.3 +/- 0.6%/day, the protein FSR was 8.0 +/- 3.5%/day, and the net protein deposition (FSR - FBR) was -0.3 +/- 3.7%/day. These values were lower (P < .01 to .05) than the corresponding values in the control group (DNA FSR: 2.9 +/- 0.9%/day; protein FSR: 20.5 +/- 8.4%/day; net protein deposition: 7.9 +/- 6.0%/day). Sulfamylon cream selectively inhibited DNA FSR from the de novo base synthesis pathway (2.3 +/- 1.2 vs 0.8 +/- 0.5%/day, P < .05 vs control). With the occlusive dressing Sulfamylon cream did not decrease wound DNA FSR due to a stimulation of the base salvage pathway, but still decreased protein FSR (11.5 +/- 5.1%/day, P < .05 vs control). Histologic slides indicated that Sulfamylon cream inhibited re-epithelialization, collagen formation, and angiogenesis in the wound.
Topical Sulfamylon cream application inhibited DNA and protein synthesis in the wound, which would be expected to retard the healing process.
尽管磺胺米隆对烧伤创面感染有效，但关于其对愈合过程的影响仍存在争议。
在全身麻醉下，于兔背部制造部分厚度皮肤供皮区创面，并在颈动脉和颈静脉置入留置导管。将磺胺米隆乳膏（8.5%，BERTEK制药公司，西弗吉尼亚州摩根敦）以开放或封闭敷料方式应用于创面上。对照创面仅覆盖敷料。伤后第7天，输注稳定同位素示踪剂以测定创面DNA的分数合成率（FSR）以及蛋白质的FSR和分数分解率（FBR）。
在磺胺米隆-开放敷料组中，DNA FSR为1.3±0.6%/天，蛋白质FSR为8.0±3.5%/天，蛋白质净沉积（FSR - FBR）为-0.3±3.7%/天。这些值低于（P <.01至.05）对照组的相应值（DNA FSR：2.9±0.9%/天；蛋白质FSR：20.5±8.4%/天；蛋白质净沉积：7.9±6.0%/天）。磺胺米隆乳膏从从头碱基合成途径选择性抑制DNA FSR（2.3±1.2对0.8±0.5%/天，与对照组相比P <.05）。使用封闭敷料时，由于碱基补救途径的刺激，磺胺米隆乳膏未降低创面DNA FSR，但仍降低了蛋白质FSR（11.5±5.1%/天，与对照组相比P <.05）。组织学切片表明，磺胺米隆乳膏抑制创面的再上皮化、胶原形成和血管生成。
局部应用磺胺米隆乳膏抑制创面DNA和蛋白质合成，这有望延缓愈合过程。
Zotero 插件