Huang Z Josh
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Neuron. 2006 May 18;50(4):521-4. doi: 10.1016/j.neuron.2006.05.005.
The metabotropic GABAB receptors mediate slow synaptic inhibition and consist of heterodimers of GABAB1 and GABAB2 subunits. The only known molecular diversity of the GABAB receptors arises from the two GABAB1 isoforms, but its functional significance has been unclear. Two studies in this issue of Neuron now demonstrate that GABAB1a and GABAB1b show strategically distinct subcellular localization and physiological action.
代谢型GABAB受体介导缓慢的突触抑制，由GABAB1和GABAB2亚基的异二聚体组成。GABAB受体唯一已知的分子多样性源于两种GABAB1亚型，但其功能意义尚不清楚。本期《神经元》杂志上的两项研究现已表明，GABAB1a和GABAB1b在亚细胞定位和生理作用上表现出策略性的明显差异。
