Rand David M, Haney Robert A, Fry Adam J
Department of Ecology and Evolutionary Biology, Box G-W, 80 Waterman Street, Brown University, Providence, RI 02912, USA.
Trends Ecol Evol. 2004 Dec;19(12):645-53. doi: 10.1016/j.tree.2004.10.003.
Without mitochondria we would be in big trouble, and there would be a global biological energy crisis if it were not for chloroplasts. Fortunately, genomic evolution over the past two billion years has ensured that the functions of these key organelles are with us to stay. Whole-genome analyses have not only proven that mitochondria and chloroplasts are descended from formerly free-living bacteria, but have also shown that it is difficult to define eukaryotes without reference to the fusion and coevolution of host and endosymbiont genomes. Here, we review how the macro- and microevolutionary insights that follow from the genomics of cytonuclear interactions are uniting molecular evolution, structural proteomics, population genetics and problems in aging and disease. Our goals are to clarify the coevolutionary events that have governed nuclear and organelle evolution, and to encourage further critical analyses of these interactions as problems in the study of co-adapted gene complexes.
没有线粒体，我们将陷入巨大困境；如果没有叶绿体，将会出现全球生物能源危机。幸运的是，过去二十亿年的基因组进化确保了这些关键细胞器的功能将一直与我们相伴。全基因组分析不仅证明了线粒体和叶绿体起源于曾经自由生活的细菌，还表明如果不考虑宿主和内共生体基因组的融合与共同进化，就很难定义真核生物。在这里，我们回顾了从细胞核与细胞器相互作用的基因组学中获得的宏观和微观进化见解如何将分子进化、结构蛋白质组学、群体遗传学以及衰老和疾病问题联系起来。我们的目标是阐明支配细胞核和细胞器进化的共同进化事件，并鼓励将这些相互作用作为共同适应基因复合体研究中的问题进行进一步的批判性分析。
