Nowak Adriana, Libudzisz Zdzislawa
Department of Biotechnology and Food Sciences, Institute of Fermentation Technology and Microbiology, Technical University of Lodz, ul. Wolczanska 171/173, 90-924 Lodz, Poland.
Anaerobe. 2006 Apr;12(2):80-4. doi: 10.1016/j.anaerobe.2005.10.003. Epub 2006 Feb 21.
Some intestinal bacteria can produce many genotoxic, mutagenic and carcinogenic substances. The major products of the bacterial aromatic amino acids fermentation-phenolic and indolic compounds which are responsible for colon cancer development are accumulated in the colon. The effect of phenol, p-cresol and indole (2, 20 and 100 microg/ml doses) on growth and survival of four strains of intestinal lactic acid bacteria was studied. Growth of bacteria was not affected by any of the concentrations of phenol and p-cresol tested. The growth of 2 strains was slightly inhibited by 100 microg/ml of indole. There was no influence of phenol and p-cresol on survival of lactic bacteria until 120 h and specific reaction to carcinogens depending on strain was observed after that incubation time. Indole concentrations 20 and 100 microg/ml appeared to be toxic for all tested strains but just after 24, 48 or 72 h of incubation depending on the strain. In total, 2 microg/ml of indole had a very little effect.
