Kloas Werner, Lutz Ilka
Department of Endocrinology, Institute of Biology, Humboldt University, Invalidenstrasse 42, Berlin 10099, Germany.
J Chromatogr A. 2006 Oct 13;1130(1):16-27. doi: 10.1016/j.chroma.2006.04.001. Epub 2006 May 15.
Environmental compounds can interfere with endocrine systems of wildlife and humans. These so-called endocrine disrupters (ED) are known to affect reproductive biology and thyroid system. The classical model species for these endocrine systems are amphibians and therefore they can serve as sentinels for detection of the modes of action (MOAs) of ED. Recently, amphibians are being reviewed as suitable models to assess (anti)estrogenic and (anti)androgenic MOAs influencing reproductive biology as well as (anti)thyroidal MOAs interfering with the thyroid system. The development of targeted bioassays in combination with adequate chemical analyses is the prerequisite for a concise risk assessment of ED.
环境化合物会干扰野生动物和人类的内分泌系统。这些所谓的内分泌干扰物（ED）已知会影响生殖生物学和甲状腺系统。这些内分泌系统的经典模式生物是两栖动物，因此它们可作为检测内分泌干扰物作用模式（MOA）的哨兵。最近，两栖动物正被重新评估为评估影响生殖生物学的（抗）雌激素和（抗）雄激素作用模式以及干扰甲状腺系统的（抗）甲状腺作用模式的合适模型。结合适当化学分析开发靶向生物测定法是对内分泌干扰物进行精确风险评估的前提条件。
