Ranade Shrirang V, Richard Robert E, Helmus Michael N
Corporate Research and Advanced Technology Development, Boston Scientific Corporation, 1 Boston Scientific Place, Natick, MA 01760, USA.
Acta Biomater. 2005 Jan;1(1):137-44. doi: 10.1016/j.actbio.2004.09.004.
The use of styrenic block copolymers has undergone a renaissance as a biomaterial and drug delivery matrix. The early promise posed by the physical and biological properties of these block copolymers for implantable medical devices was not met. However, there has been an increased understanding of the role of microphase separation on the mediation of the biological response. Poly (styrene-b-isobutylene-b-styrene) (SIBS) block copolymer has critical enabling properties related to processing, vascular compatibility and bio-stability that has resulted in its use as the matrix for paclitaxel delivery from Boston Scientific's TAXUS coronary stent. These enabling properties will allow the continuing development of medical devices based on SIBS that meet demanding physical and biological requirements.
苯乙烯类嵌段共聚物作为一种生物材料和药物递送基质正经历复兴。这些嵌段共聚物的物理和生物学特性曾为可植入医疗设备带来早期希望，但并未实现。然而，人们对微相分离在介导生物学反应中的作用有了更多了解。聚（苯乙烯-嵌段-异丁烯-嵌段-苯乙烯）（SIBS）嵌段共聚物具有与加工、血管相容性和生物稳定性相关的关键特性，这使其成为波士顿科学公司TAXUS冠状动脉支架中紫杉醇递送的基质。这些特性将推动基于SIBS的医疗设备持续发展，以满足严格的物理和生物学要求。
