Navarro M, Ginebra M P, Planell J A, Barrias C C, Barbosa M A
Reference Centre for Bioengineering of Catalonia (CREBEC), Biomaterials, Biomechanics and Tissue Engineering Division, Department of Materials Science, Universitat Politècnica de Catalunya, Barcelona, Spain.
Acta Biomater. 2005 Jul;1(4):411-9. doi: 10.1016/j.actbio.2005.03.004.
Poly(alpha-hydroxy acids), and in particular polylactic acid (PLA), are nowadays amongst the most used bioabsorbable materials. However, this polymer may not meet some application requirements due to inadequate mechanical properties and or its degradation characteristics. A possible strategy to tackle this problem is the incorporation of an inorganic phase into the polymeric matrix. In this work a new fully biodegradable composite material made with PLA and calcium phosphate soluble glass particles has been developed. The behaviour of the PLA/glass composite has been analysed during its degradation in simulated physiological conditions by means of weight loss, molecular weight and thermal properties analysis and electron microscopy observation. The results showed that the incorporation of phosphate glass particles into the polymer significantly accelerated the degradation of the PLA and induced the formation of calcium phosphate precipitates at the composite surface.
聚（α-羟基酸），尤其是聚乳酸（PLA），如今是最常用的生物可吸收材料之一。然而，由于机械性能不足和/或其降解特性，这种聚合物可能无法满足某些应用要求。解决这个问题的一种可能策略是将无机相引入聚合物基体中。在这项工作中，已经开发出一种由PLA和磷酸钙可溶性玻璃颗粒制成的新型完全可生物降解复合材料。通过失重、分子量和热性能分析以及电子显微镜观察，分析了PLA/玻璃复合材料在模拟生理条件下的降解行为。结果表明，将磷酸盐玻璃颗粒引入聚合物中显著加速了PLA的降解，并在复合材料表面诱导形成了磷酸钙沉淀。
