• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Excitatory P2-receptors at sympathetic axon terminals: role in temperature control of cutaneous blood flow.交感神经轴突末梢处的兴奋性P2受体：在皮肤血流温度调控中的作用
Br J Pharmacol. 2006 Jul;148(5):561-2. doi: 10.1038/sj.bjp.0706767. Epub 2006 May 15.
2
Local regulation of skin blood flow during cooling involving presynaptic P2 purinoceptors in rats.大鼠冷却过程中涉及突触前P2嘌呤能受体的皮肤血流局部调节。
Br J Pharmacol. 2006 Jul;148(5):579-86. doi: 10.1038/sj.bjp.0706765. Epub 2006 May 15.
3
Role of the purinergic and noradrenergic components in the potentiation by endothelin-1 of the sympathetic contraction of the rabbit central ear artery during cooling.嘌呤能和去甲肾上腺素能成分在冷却过程中内皮素-1增强兔中耳动脉交感收缩中的作用。
Br J Pharmacol. 1997 Sep;122(1):172-8. doi: 10.1038/sj.bjp.0701359.
4
P2-purinoceptors on postganglionic sympathetic neurones.节后交感神经元上的P2嘌呤受体
J Auton Pharmacol. 1996 Dec;16(6):413-6. doi: 10.1111/j.1474-8673.1996.tb00065.x.
5
Thermoregulatory control of sympathetic fibres supplying the rat's tail.供应大鼠尾巴的交感神经纤维的体温调节控制。
J Physiol. 2002 Sep 15;543(Pt 3):849-58. doi: 10.1113/jphysiol.2002.023770.
6
Sympathetic purinergic vasoconstriction and thermosensitivity in a canine cutaneous vein.犬皮肤静脉中的交感嘌呤能血管收缩与热敏感性
J Pharmacol Exp Ther. 1986 Dec;239(3):784-9.
7
Regulation of the cutaneous circulation.皮肤循环的调节
Fed Proc. 1986 Dec;45(13):2841-50.
8
Independent vasomotor control of rat tail and proximal hairy skin.大鼠尾部和近端多毛皮肤的独立血管舒缩控制
J Physiol. 2007 Jul 1;582(Pt 1):421-33. doi: 10.1113/jphysiol.2007.131292. Epub 2007 Apr 12.
9
Effect of cooling on cutaneous microvascular adrenoceptors in vivo in the rabbit ear.冷却对兔耳体内皮肤微血管肾上腺素能受体的影响。
J Orthop Res. 1998 Mar;16(2):190-6. doi: 10.1002/jor.1100160206.
10
Immersion of the hand in ice water releases adrenergic vasoconstrictor tone in the ipsilateral temple.将手浸入冰水中会释放同侧颞部的肾上腺素能血管收缩张力。
Auton Neurosci. 2006 Jul 30;128(1-2):70-5. doi: 10.1016/j.autneu.2006.03.002. Epub 2006 Apr 19.

引用本文的文献

1
Role of the purinergic P2Y2 receptor in hippocampal function in mice.嘌呤能P2Y2受体在小鼠海马功能中的作用。
Eur Rev Med Pharmacol Sci. 2020 Nov;24(22):11858-11864. doi: 10.26355/eurrev_202011_23843.

本文引用的文献

1
Local regulation of skin blood flow during cooling involving presynaptic P2 purinoceptors in rats.大鼠冷却过程中涉及突触前P2嘌呤能受体的皮肤血流局部调节。
Br J Pharmacol. 2006 Jul;148(5):579-86. doi: 10.1038/sj.bjp.0706765. Epub 2006 May 15.
2
Pharmacological profiles of cloned mammalian P2Y-receptor subtypes.克隆的哺乳动物P2Y受体亚型的药理学特征。
Pharmacol Ther. 2006 Jun;110(3):415-32. doi: 10.1016/j.pharmthera.2005.08.014. Epub 2005 Oct 28.
3
Rho kinase mediates cold-induced constriction of cutaneous arteries: role of alpha2C-adrenoceptor translocation.Rho激酶介导寒冷诱导的皮肤动脉收缩：α2C肾上腺素能受体易位的作用。
Circ Res. 2004 May 28;94(10):1367-74. doi: 10.1161/01.RES.0000128407.45014.58. Epub 2004 Apr 15.
4
Heterogeneity of P2X receptors in sympathetic neurons: contribution of neuronal P2X1 receptors revealed using knockout mice.交感神经元中P2X受体的异质性：利用基因敲除小鼠揭示神经元P2X1受体的作用
Mol Pharmacol. 2004 Jan;65(1):139-48. doi: 10.1124/mol.65.1.139.
5
ATP modulates noradrenaline release by activation of inhibitory P2Y receptors and facilitatory P2X receptors in the rat vas deferens.三磷酸腺苷（ATP）通过激活大鼠输精管中的抑制性P2Y受体和促进性P2X受体来调节去甲肾上腺素的释放。
J Pharmacol Exp Ther. 2003 Nov;307(2):809-15. doi: 10.1124/jpet.103.054809. Epub 2003 Sep 9.
6
Attenuation of the P2Y receptor-mediated control of neuronal Ca2+ channels in PC12 cells by antithrombotic drugs.抗血栓药物对PC12细胞中P2Y受体介导的神经元Ca2+通道控制的减弱作用。
Br J Pharmacol. 2003 Jan;138(2):343-50. doi: 10.1038/sj.bjp.0705037.
7
P2Y-receptors mediating an inhibition of the evoked entry of calcium through N-type calcium channels at neuronal processes.P2Y受体介导对通过神经元突起处N型钙通道诱发的钙内流的抑制作用。
J Pharmacol Exp Ther. 2002 Nov;303(2):520-6. doi: 10.1124/jpet.102.037960.
8
Molecular physiology of P2X receptors.P2X受体的分子生理学
Physiol Rev. 2002 Oct;82(4):1013-67. doi: 10.1152/physrev.00015.2002.
9
P2X(2), P2X(2-2) and P2X(5) receptor subunit expression and function in rat thoracolumbar sympathetic neurons.P2X(2)、P2X(2-2)和P2X(5)受体亚基在大鼠胸腰段交感神经元中的表达及功能
J Neurochem. 2001 Dec;79(5):997-1003. doi: 10.1046/j.1471-4159.2001.00653.x.
10
Evidence that release of adenosine triphosphate from endothelial cells during increased shear stress is vesicular.有证据表明，在内皮细胞中，当剪切应力增加时，三磷酸腺苷的释放是通过囊泡进行的。
J Cardiovasc Pharmacol. 2001 Dec;38(6):900-8. doi: 10.1097/00005344-200112000-00012.

交感神经轴突末梢处的兴奋性P2受体：在皮肤血流温度调控中的作用

Excitatory P2-receptors at sympathetic axon terminals: role in temperature control of cutaneous blood flow.

作者信息

von Kügelgen Ivar

机构信息

Department of Pharmacology, University of Bonn, Reuterstrasse 2b, Bonn D-53113, Germany.

出版信息

Br J Pharmacol. 2006 Jul;148(5):561-2. doi: 10.1038/sj.bjp.0706767. Epub 2006 May 15.

DOI:10.1038/sj.bjp.0706767
PMID:16702989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1751880/
Abstract

The mechanisms underlying the reduction in cutaneous blood flow in response to cooling are only partially understood. A study published in this issue of the British Journal of Pharmacology now provides evidence for the involvement of excitatory P2-receptors located at sympathetic axon terminals in the cooling-induced vasoconstriction in the skin. Cooling appears to cause the release of adenine nucleotides followed by the activation of excitatory presynaptic P2-receptors at noradrenergic axon terminals. Activation of these excitatory P2-receptors induces the release of noradrenaline, which subsequently causes constriction of blood vessels in the skin by action on smooth muscle alpha(1)- and alpha(2)-adrenoceptors. The commentary discusses the implication of the results and remaining questions.

摘要

皮肤血流对冷却作出反应时减少的潜在机制仅得到部分理解。本期《英国药理学杂志》发表的一项研究现在提供了证据，表明位于交感神经轴突末端的兴奋性P2受体参与了皮肤冷却诱导的血管收缩。冷却似乎导致腺嘌呤核苷酸的释放，随后去甲肾上腺素能轴突末端的兴奋性突触前P2受体被激活。这些兴奋性P2受体的激活诱导去甲肾上腺素的释放，去甲肾上腺素随后通过作用于平滑肌α(1)和α(2)肾上腺素能受体而导致皮肤血管收缩。该评论讨论了这些结果的意义以及尚存的问题。