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[骨质疏松症的诊断新技术]

[New techniques for the diagnosis of osteoporosis].

作者信息

Issever A S, Link T M

机构信息

Institut für Radiologie am Campus Mitte, Klinikum Charité der Universitätsmedizin Berlin.

出版信息

Radiologe. 2006 Oct;46(10):870, 872-80. doi: 10.1007/s00117-006-1374-7.

DOI:10.1007/s00117-006-1374-7
PMID:16703340
Abstract

In this review article current developments and applications in quantitative osteoporosis imaging are presented. Developments in the field of DXA include geometrical parameters of the proximal femur such as the "hip axis length" and new ROIs to determine BMD. Advances in QCT are new volumetric techniques to quantify BMD at the lumbar spine and the proximal femur. In addition techniques to determine BMD in standard contrast-enhanced abdominal computed tomography studies are described. Currently with the new bone quality concept in full bloom techniques to quantify trabecular bone architecture as new surrogates of bone strength are of increasing significance. Spatial high-resolution techniques such as magnetic resonance imaging and new computed tomography techniques have shown their potential in assessing trabecular bone structure. In addition ultrasound is considered a low-cost technique to explore bone quality.

摘要

在这篇综述文章中,介绍了定量骨质疏松成像的当前发展和应用。双能X线吸收法(DXA)领域的发展包括股骨近端的几何参数,如“髋轴长度”,以及用于确定骨密度(BMD)的新感兴趣区域(ROI)。定量计算机断层扫描(QCT)的进展是用于量化腰椎和股骨近端骨密度的新容积技术。此外,还描述了在标准对比增强腹部计算机断层扫描研究中确定骨密度的技术。目前,随着新的骨质量概念的蓬勃发展,作为骨强度新替代指标的量化小梁骨结构的技术变得越来越重要。空间高分辨率技术,如磁共振成像和新的计算机断层扫描技术,已显示出它们在评估小梁骨结构方面的潜力。此外,超声被认为是一种探索骨质量的低成本技术。

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引用本文的文献

1
[Introduction to the topic: diagnosis of osteoporosis - a paradigm shift].[主题介绍:骨质疏松症的诊断——范式转变]
Radiologe. 2006 Oct;46(10):829-30. doi: 10.1007/s00117-006-1388-1.

本文引用的文献

1
Trabecular bone structure of the calcaneus: comparison of MR imaging at 3.0 and 1.5 T with micro-CT as the standard of reference.跟骨小梁骨结构:以微型计算机断层扫描为参考标准比较3.0T和1.5T磁共振成像
Radiology. 2006 May;239(2):488-96. doi: 10.1148/radiol.2392050574. Epub 2006 Mar 28.
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Strontium ranelate--data on vertebral and nonvertebral fracture efficacy and safety: mechanism of action.
Curr Osteoporos Rep. 2006 Mar;4(1):34-9. doi: 10.1007/s11914-006-0013-6.
3
Serum cathepsin K concentrations reflect osteoclastic activity in women with postmenopausal osteoporosis and patients with Paget's disease.血清组织蛋白酶K浓度反映绝经后骨质疏松症女性和佩吉特病患者的破骨细胞活性。
Clin Lab. 2006;52(1-2):1-10.
4
Structural analysis of trabecular bone of the proximal femur using multislice computed tomography: a comparison with dual X-ray absorptiometry for predicting biomechanical strength in vitro.使用多层计算机断层扫描对近端股骨小梁骨进行结构分析:与双能X线吸收法在体外预测生物力学强度的比较。
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Strontium ranelate: an increased bone quality leading to vertebral antifracture efficacy at all stages.雷奈酸锶:在各个阶段均可提高骨质量,从而产生椎体抗骨折疗效。
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Femur strength index predicts hip fracture independent of bone density and hip axis length.股骨强度指数可独立于骨密度和髋轴长度预测髋部骨折。
Osteoporos Int. 2006;17(4):593-9. doi: 10.1007/s00198-005-0019-4. Epub 2005 Dec 31.
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The role of collagen in bone strength.胶原蛋白在骨强度中的作用。
Osteoporos Int. 2006;17(3):319-36. doi: 10.1007/s00198-005-2035-9. Epub 2005 Dec 9.
8
[The prevalence of osteoporosis and associated health care use in women 45 years and older in Germany. Results of the first German Telephone Health Survey 2003].[德国45岁及以上女性骨质疏松症患病率及相关医疗保健利用情况。2003年首次德国电话健康调查结果]
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2005 Dec;48(12):1338-47. doi: 10.1007/s00103-005-1166-7.
9
Improved performance of hip DXA using a novel region of interest in the upper part of the femoral neck: in vitro study using bone strength as a standard of reference.利用股骨颈上部的新型感兴趣区域提高髋部双能X线吸收法的性能:以骨强度作为参考标准的体外研究
J Clin Densitom. 2005 Winter;8(4):488-94. doi: 10.1385/jcd:8:4:488.
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Bone metabolism, vascular calcifications and mortality: associations beyond mere coincidence.骨代谢、血管钙化与死亡率:关联绝非偶然。
J Nephrol. 2005 Jul-Aug;18(4):458-63.