透明质酸钠（Ophthalin）和羟丙基甲基纤维素（HPMC-Ophtal）对白内障超声乳化术后角膜内皮、中央角膜厚度及眼压影响的比较。

Comparison of the effect of sodium hyaluronate (Ophthalin) and hydroxypropylmethylcellulose (HPMC-Ophtal) on corneal endothelium, central corneal thickness, and intraocular pressure after phacoemulsification.

作者信息

Ray-Chaudhuri N, Voros G M, Sutherland S, Figueiredo F C

机构信息

Department of Ophthalmology, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.

出版信息

Eur J Ophthalmol. 2006 Mar-Apr;16(2):239-46. doi: 10.1177/112067210601600208.

DOI:10.1177/112067210601600208

PMID:16703541

Abstract

PURPOSE

To prospectively evaluate the effects of 2% hydroxypropyl-methylcellulose (HPMC-Ophtal) and sodium hyaluronate 1% (Ophthalin) on intraocular pressure, corneal thickness, and endothelial cell loss in small incision cataract surgery with implant.

METHODS

A total of 110 patients undergoing routine phacoemulsification with implant received either 2% hydroxypropyl methylcellulose or sodium hyaluronate 1% as ophthalmic viscosurgical device. Pre- and postoperative slitlamp examination, intraocular pressure measurement (preoperatively and at 1-4 hours, 1 day, and 7 days postoperatively), ultrasonic pachymetry (preoperatively and at 1 week, 4-6 weeks, and 12 weeks post operatively), and corneal endothelial cell count (preoperatively and 12 weeks postoperatively) were performed. Data were analyzed using two-way analysis of variance.

RESULTS

All measurements were comparable between the two groups preoperatively. Intraocular pressure was significantly lower in the Ophthalin group at 1 day post operatively, while no significant difference was found between the two groups on the 1-4 hours and 7 days examination. The central corneal thickness was not significantly different between the two groups at any postoperative visit . However, the mean cell density demonstrated a significant fall of 11.76% for Ophthalin and 4.27% for HPMC-Ophtal at 12 weeks post-operatively, the difference between the two being significant (p=0.009).

CONCLUSIONS

2% Hydroxypropyl methylcellulose, compared with sodium hyaluronate 1%, is superior in protecting the corneal endothelial cells, has the same effect on central corneal thickness, and is associated with slightly higher intraocular pressure 1 day post operatively. It compares favorably with sodium hyaluronate 1% and can be used as an effective and cheaper alternative in routine small incision cataract surgery with implant.

摘要

目的

前瞻性评估2%羟丙基甲基纤维素（HPMC-Ophtal）和1%透明质酸钠（Ophthalin）在小切口白内障植入手术中对眼压、角膜厚度和内皮细胞损失的影响。

方法

总共110例行常规超声乳化白内障植入手术的患者接受了2%羟丙基甲基纤维素或1%透明质酸钠作为眼科粘弹剂。术前及术后进行裂隙灯检查、眼压测量（术前、术后1-4小时、1天和7天）、超声角膜测厚（术前、术后1周、4-6周和12周）以及角膜内皮细胞计数（术前和术后12周）。数据采用双向方差分析进行分析。

结果

两组术前所有测量值均具有可比性。术后1天Ophthalin组眼压显著较低，而在术后1-4小时和7天检查时两组之间未发现显著差异。术后任何时间点两组中央角膜厚度均无显著差异。然而，术后12周时，Ophthalin组平均细胞密度显著下降了11.76%，HPMC-Ophtal组下降了4.27%，两组之间差异显著（p=0.009）。