Diamond Alan, Kenney Christopher, Jankovic Joseph
Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA.
Mov Disord. 2006 Aug;21(8):1273-5. doi: 10.1002/mds.20949.
We report on a 30-year-old man with Tourette's syndrome (TS) and medication-refractory epilepsy whose tics improved after implantation of a vagal nerve stimulator (VNS). To verify the patient's observation, we performed a blinded video assessment using the modified Rush video-based tic rating scale. The patient underwent two separate video recordings (VNS on and VNS off). A rater, blinded to patient's VNS status, evaluated the videos with the modified Rush video-based tic rating scale. There were improvements in total tic score and motor and phonic tic frequency. If verified by controlled clinical trials, this observation may provide insights into the pathophysiology of tics and may lead to a novel therapy for patients with severe TS.
我们报告了一名患有妥瑞氏症（TS）和药物难治性癫痫的30岁男性，其在植入迷走神经刺激器（VNS）后抽动症状有所改善。为了验证患者的观察结果，我们使用改良的基于拉什视频的抽动评定量表进行了盲法视频评估。该患者进行了两次单独的视频记录（VNS开启和VNS关闭）。一名对患者VNS状态不知情的评估者使用改良的基于拉什视频的抽动评定量表对视频进行评估。总抽动评分以及运动性和发声性抽动频率均有改善。如果经对照临床试验证实，这一观察结果可能为抽动的病理生理学提供见解，并可能为重度TS患者带来新的治疗方法。
