Liszka Łukasz, Woszczyk Dariusz, Pajak Jacek
Department of Pathomorphology, Medical University of Silesia, Katowice, Poland.
J Gastroenterol Hepatol. 2006 May;21(5):792-7. doi: 10.1111/j.1440-1746.2006.04332.x.
A typical symptom of microscopic colitis (MC) is chronic watery diarrhea with normal endoscopic findings and characteristic inflammatory changes in histopathology. Treatment of the disease is mainly empiric. MC has two main subtypes: lymphocytic colitis and collagenous colitis. There are also untypical histopathological forms of MC: MC with giant cells, MC not otherwise specified (NOS) and cryptal lymphocytic coloproctitis. Some other histopathological changes in MC have been observed, especially Paneth cell hyperplasia or epithelial degeneration. Eosinophilic colitis, acute colitis, amyloidosis, ulcerative colitis and Crohn's disease should be taken into consideration in differential diagnosis. The most reliable biopsy material for histopathological examination are samples obtained from transverse colon. Some studies proved that treatment of MC makes it possible to reduce not only clinical, but also histopathological, manifestations.
显微镜下结肠炎（MC）的典型症状是慢性水样腹泻，内镜检查结果正常，组织病理学有特征性炎症改变。该病的治疗主要是经验性的。MC有两种主要亚型：淋巴细胞性结肠炎和胶原性结肠炎。MC还有非典型组织病理学形式：伴有巨细胞的MC、未另行特指（NOS）的MC和隐窝淋巴细胞性结肠直肠炎。在MC中还观察到一些其他组织病理学变化，尤其是潘氏细胞增生或上皮变性。鉴别诊断时应考虑嗜酸性结肠炎、急性结肠炎、淀粉样变性、溃疡性结肠炎和克罗恩病。组织病理学检查最可靠的活检材料是取自横结肠的样本。一些研究证明，MC的治疗不仅可以减轻临床症状，还可以减轻组织病理学表现。
