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[显微镜下结肠炎:胶原性结肠炎和淋巴细胞性结肠炎]

[Microscopic colitis: collagenous colitis and lymphocytic colitis].

作者信息

Chatelain Denis, Mokrani Nassima, Fléjou Jean-François

机构信息

Service d'anatomie pathologique, CHU d'Amiens, Place Victor-Pauchet, 80054 Amiens cedex 01.

出版信息

Ann Pathol. 2007 Dec;27(6):448-58. doi: 10.1016/S0242-6498(07)71417-7.

Abstract

Microscopic colitis is currently classified as a chronic inflammatory bowel disorder and encompasses two entities: lymphocytic colitis and collagenous colitis. Patients with microscopic colitis present with a well-tolerated chronic watery diarrhea, sometimes with abdominal pain. Colonoscopy is normal. Diagnosis of microscopic colitis is established by histologic examination of colonic biopsies, showing a thickened subsurface collagen band higher than 10 microm in collagenous colitis, and an increased number of surface intra-epithelial lymphocytes higher than 20 lymphocytes per 100 epithelial cells in lymphocytic colitis. Causes of microscopic colitis are still unknown, although a drug-induced etiology is found in some cases. Patients are usually treated with budesonide but recurrences are frequent.

摘要

显微镜下结肠炎目前被归类为一种慢性炎症性肠病,包括两种类型:淋巴细胞性结肠炎和胶原性结肠炎。显微镜下结肠炎患者表现为耐受性良好的慢性水样腹泻,有时伴有腹痛。结肠镜检查结果正常。显微镜下结肠炎的诊断通过结肠活检的组织学检查来确定,在胶原性结肠炎中显示黏膜下胶原带增厚超过10微米,在淋巴细胞性结肠炎中显示每100个上皮细胞中表面上皮内淋巴细胞数量增加超过20个。显微镜下结肠炎的病因仍然未知,尽管在某些病例中发现了药物性病因。患者通常用布地奈德治疗,但复发很常见。

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