Chatelain Denis, Mokrani Nassima, Fléjou Jean-François
Service d'anatomie pathologique, CHU d'Amiens, Place Victor-Pauchet, 80054 Amiens cedex 01.
Ann Pathol. 2007 Dec;27(6):448-58. doi: 10.1016/S0242-6498(07)71417-7.
Microscopic colitis is currently classified as a chronic inflammatory bowel disorder and encompasses two entities: lymphocytic colitis and collagenous colitis. Patients with microscopic colitis present with a well-tolerated chronic watery diarrhea, sometimes with abdominal pain. Colonoscopy is normal. Diagnosis of microscopic colitis is established by histologic examination of colonic biopsies, showing a thickened subsurface collagen band higher than 10 microm in collagenous colitis, and an increased number of surface intra-epithelial lymphocytes higher than 20 lymphocytes per 100 epithelial cells in lymphocytic colitis. Causes of microscopic colitis are still unknown, although a drug-induced etiology is found in some cases. Patients are usually treated with budesonide but recurrences are frequent.
显微镜下结肠炎目前被归类为一种慢性炎症性肠病，包括两种类型：淋巴细胞性结肠炎和胶原性结肠炎。显微镜下结肠炎患者表现为耐受性良好的慢性水样腹泻，有时伴有腹痛。结肠镜检查结果正常。显微镜下结肠炎的诊断通过结肠活检的组织学检查来确定，在胶原性结肠炎中显示黏膜下胶原带增厚超过10微米，在淋巴细胞性结肠炎中显示每100个上皮细胞中表面上皮内淋巴细胞数量增加超过20个。显微镜下结肠炎的病因仍然未知，尽管在某些病例中发现了药物性病因。患者通常用布地奈德治疗，但复发很常见。
