Svartberg J, von Mühlen D, Mathiesen E, Joakimsen O, Bønaa K H, Stensland-Bugge E
Department of Medicine, University Hospital of North Norway, Tromsø, Norway.
J Intern Med. 2006 Jun;259(6):576-82. doi: 10.1111/j.1365-2796.2006.01637.x.
To study the relationship between endogenous sex hormone levels and intima-media thickness (IMT) of the carotid artery measured by ultrasonography.
Population-based cross-sectional study.
Sex hormone levels measured by immunoassay, anthropometric measurements and IMT was studied in 1482 men aged 25-84 years participating in the 1994-1995 Tromsø study. The data were analysed with partial correlation, multiple linear regression and logistic regression analysis.
Linear regression models showed that total testosterone and sex hormone-binding globulin levels, but not calculated free testosterone, serum oestradiol or dehydroepiandrosterone sulphate levels were inversely associated with the age-adjusted IMT (P = 0.008 and P < 0.001 respectively). These associations were independent of smoking, physical activity, blood pressure and lipid levels, but were not independent of body mass index (BMI). Excluding men with cardiovascular disease (CVD) did not materially change these results. In a logistic regression model adjusted for the confounding effect of CVD risk factors, men with testosterone levels in the lowest quintile (<9.0 nmol L(-1)) had an independent OR = 1.51 (P = 0.015) of being in the highest IMT quintile.
We found an inverse association between total testosterone levels and IMT of the carotid artery in men that was present also after excluding men with CVD, but was not independent of BMI. The clinical relevance of this, however, is uncertain and needs to be investigated in a clinical setting.
研究内源性性激素水平与通过超声测量的颈动脉内膜中层厚度（IMT）之间的关系。
基于人群的横断面研究。
对参与1994 - 1995年特罗姆瑟研究的1482名年龄在25 - 84岁的男性进行免疫分析法测定性激素水平、人体测量以及IMT研究。采用偏相关分析、多元线性回归分析和逻辑回归分析对数据进行分析。
线性回归模型显示，总睾酮和性激素结合球蛋白水平与年龄校正后的IMT呈负相关，而计算得出的游离睾酮、血清雌二醇或硫酸脱氢表雄酮水平与年龄校正后的IMT无此关联（分别为P = 0.008和P < 0.001）。这些关联独立于吸烟、体力活动、血压和血脂水平，但不独立于体重指数（BMI）。排除患有心血管疾病（CVD）的男性后，这些结果没有实质性变化。在调整了CVD危险因素混杂效应的逻辑回归模型中，睾酮水平处于最低五分位数（<9.0 nmol/L）的男性处于最高IMT五分位数的独立比值比（OR）为1.51（P = 0.015）。
我们发现男性总睾酮水平与颈动脉IMT之间存在负相关，在排除患有CVD的男性后这种关联依然存在，但不独立于BMI。然而，其临床相关性尚不确定，需要在临床环境中进行研究。
