Pöykkö S M, Kellokoski E, Ukkola O, Kauma H, Päivänsalo M, Kesäniemi Y A, Hörkkö S
Department of Internal Medicine, University of Oulu, Oulu, Finland.
J Intern Med. 2006 Jul;260(1):43-52. doi: 10.1111/j.1365-2796.2006.01661.x.
Ghrelin, a peptide hormone from stomach, stimulates food intake and decreases fat utilization. Ghrelin binds to growth hormone secretagogue receptor (GHSR). GHSR density has been shown to be upregulated in atherosclerotic lesions, but the relationship between ghrelin concentration and atherosclerosis has not yet been studied. We, therefore, characterized the association between ghrelin concentration and carotid artery intima-media thickness (IMT) in a population-based cohort of 1024 middle-aged (40-60 years) men and women.
Intima-media thickness and the number of atherosclerotic plaques were determined ultrasonographically. Fasting plasma ghrelin concentrations were analysed using RIA-kit (PhoenixPeptide).
There was a positive association between mean IMT and ghrelin concentration in the analysis of males before and after adjustments for the traditional risk factors of atherosclerosis [age, systolic blood pressure, LDL cholesterol, body mass index (BMI), and smoking (ancova, P = 0.004 and P = 0.007, respectively)]. However, no such association was found in females (P = 0.985 and P = 0.915). There was no correlation between ghrelin and CRP concentrations or ghrelin and smoking.
Ghrelin concentrations and carotid artery atherosclerosis are positively associated in males even after adjustment for the commonly recognized risk factors of atherosclerosis. Experimental and prospective studies are warranted to elucidate the role of ghrelin in atherosclerosis.
胃饥饿素是一种由胃产生的肽类激素，可刺激食物摄入并降低脂肪利用率。胃饥饿素与生长激素促分泌素受体（GHSR）结合。已有研究表明，动脉粥样硬化病变中GHSR密度上调，但胃饥饿素浓度与动脉粥样硬化之间的关系尚未得到研究。因此，我们在一个基于人群的队列中，对1024名年龄在40至60岁之间的男性和女性，研究了胃饥饿素浓度与颈动脉内膜中层厚度（IMT）之间的关联。
通过超声检查确定内膜中层厚度和动脉粥样硬化斑块数量。使用RIA试剂盒（PhoenixPeptide）分析空腹血浆胃饥饿素浓度。
在对动脉粥样硬化的传统危险因素[年龄、收缩压、低密度脂蛋白胆固醇、体重指数（BMI）和吸烟]进行调整前后的男性分析中，平均IMT与胃饥饿素浓度之间存在正相关（协方差分析，P值分别为0.004和0.007）。然而，在女性中未发现这种关联（P值分别为0.985和0.915）。胃饥饿素与CRP浓度或胃饥饿素与吸烟之间无相关性。
即使在对动脉粥样硬化的公认危险因素进行调整后，男性的胃饥饿素浓度与颈动脉粥样硬化仍呈正相关。有必要进行实验性和前瞻性研究，以阐明胃饥饿素在动脉粥样硬化中的作用。
