Nguyen Rang N, Taylor Louise S, Tauschek Marija, Robins-Browne Roy M
University of Melbourne, Parkville, Victoria, Australia.
Emerg Infect Dis. 2006 Apr;12(4):597-603. doi: 10.3201/eid1204.051112.
Some clinical isolates of enteropathogenic Escherichia coli (EPEC) lack bundle-forming pili and are termed atypical EPEC. The aim of this study was to determine if atypical EPEC are pathogens by comparing the clinical features of patients infected with atypical EPEC with those of children infected with other causative agents of diarrhea. Fecal samples obtained from children attending the Royal Children's Hospital in Melbourne for investigation of diarrhea were examined for adenovirus, rotavirus, Campylobacter spp., Salmonella spp., protozoa, and pathogenic E. coli. Clinical data were obtained by using a standardized pro forma and analyzed separately. Patients infected with atypical EPEC experienced mild, nondehydrating, and noninflammatory diarrhea that was not particularly associated with fever, vomiting, or abdominal pain. However, the duration of diarrhea in patients infected with atypical EPEC was significantly longer than that caused by the other species or where no pathogens were identified. Infection with atypical EPEC is associated with prolonged diarrhea.
一些肠道致病性大肠杆菌（EPEC）临床分离株缺乏束状菌毛，被称为非典型EPEC。本研究的目的是通过比较感染非典型EPEC的患者与感染其他腹泻病原体的儿童的临床特征，来确定非典型EPEC是否为病原体。对墨尔本皇家儿童医院因腹泻前来就诊的儿童的粪便样本进行检测，以查找腺病毒、轮状病毒、弯曲杆菌属、沙门氏菌属、原生动物和致病性大肠杆菌。通过使用标准化表格获取临床数据并分别进行分析。感染非典型EPEC的患者经历轻度、非脱水性和非炎症性腹泻，且与发热、呕吐或腹痛无特别关联。然而，感染非典型EPEC的患者腹泻持续时间明显长于由其他菌种引起的腹泻或未检出病原体的情况。感染非典型EPEC与腹泻持续时间延长有关。
