Sundquist Kristina, Li Xinjun
Karolinska Institute, Center for Family and Community Medicine, Huddinge, Sweden.
Am J Prev Med. 2006 Jun;30(6):480-6. doi: 10.1016/j.amepre.2006.01.010. Epub 2006 Apr 25.
Few studies have investigated the possible differential transmission of maternal and/or paternal coronary heart disease (CHD) to offspring, after accounting for sociodemographic characteristics.
The Multigeneration Register was linked to hospital data in this study of all Swedish individuals born since 1932 and their parents. Registered cases of CHD between January 1, 1987, and December 31, 2001, were evaluated. Poisson regression was used to calculate standardized incidence ratios (SIRs) for men and women with mothers and/or fathers affected by CHD compared with men and women whose parents were not affected. All analyses were conducted in 2005.
Maternal transmission was stronger than paternal transmission and the confidence intervals did not overlap. For women, the overall SIRs were 1.43 (95% confidence interval [CI]=1.34-1.51) for maternal transmission and 1.17 (95% CI=1.11-1.23) for paternal transmission. For men, the corresponding SIRs were 1.55 (95% CI=1.50-1.60) and 1.41 (95% CI=1.37-1.45). Even higher SIRs were found in the youngest age groups, among those with both parents affected by coronary heart disease, and among those with premature parental CHD.
These findings might ultimately influence treatment decisions regarding risk factors and suggest the need for research focusing on genetic and intrauterine risk factors.
在考虑社会人口学特征之后，很少有研究调查过母亲和/或父亲的冠心病（CHD）向后代的可能差异传播情况。
在这项针对自1932年以来出生的所有瑞典个体及其父母的研究中，多代登记册与医院数据相链接。对1987年1月1日至2001年12月31日期间登记的冠心病病例进行了评估。采用泊松回归计算母亲和/或父亲患有冠心病的男性和女性与父母未患病的男性和女性相比的标准化发病率（SIR）。所有分析均在2005年进行。
母亲的传播比父亲的传播更强，且置信区间不重叠。对于女性，母亲传播的总体SIR为1.43（95%置信区间[CI]=1.34 - 1.51），父亲传播的为1.17（95%CI = 1.11 - 1.23）。对于男性，相应的SIR分别为1.55（95%CI = 1.50 - 1.60）和1.41（95%CI = 1.37 - 1.45）。在最年轻的年龄组、父母双方都患有冠心病的人群以及父母患有早发性冠心病的人群中发现了更高的SIR。
这些发现最终可能会影响关于风险因素的治疗决策，并表明需要开展侧重于遗传和宫内风险因素的研究。
