Department of Preventive Medicine, University of Sao Paulo, Brazil.
Psychol Med. 2010 Mar;40(3):477-85. doi: 10.1017/S003329170999064X. Epub 2009 Jul 23.
A consistent association between paternal age and their offspring's risk of schizophrenia has been observed, with no independent association with maternal age. The relationship of paternal and maternal ages with risk of bipolar affective disorders (BPAD) in the offspring is less clear. The present study aimed at testing the hypothesis that paternal age is associated with their offspring's risk of BPAD, whereas maternal age is not.
This population-based cohort study was conducted with individuals born in Sweden during 1973-1980 and still resident there at age 16 years. Outcome was first hospital admission with a diagnosis of BPAD. Hazard ratios (HRs) were calculated using Cox's proportional hazard regression.
After adjustment for all potential confounding variables except maternal age, the HR for risk of BPAD for each 10-year increase in paternal age was 1.28 [95% confidence interval (CI) 1.11-1.48], but this fell to 1.20 (95% CI 0.97-1.48) after adjusting for maternal age. A similar result was found for maternal age and risk of BPAD [HR 1.30 (95% CI 1.08-1.56) before adjustment for paternal age, HR 1.12 (95% CI 0.86-1.45) after adjustment]. The HR associated with having either parent aged 30 years or over was 1.26 (95% CI 1.01-1.57) and it was 1.45 (95% CI 1.16-1.81) if both parents were >30 years.
Unlike schizophrenia, the risk of BPAD seems to be associated with both paternal and maternal ages.
已有研究观察到父亲年龄与其子女患精神分裂症的风险之间存在一致的关联，而与母亲年龄则没有独立的关联。父亲和母亲年龄与子女患双相情感障碍（BPAD）的风险之间的关系则不太清楚。本研究旨在检验以下假设，即父亲年龄与子女患 BPAD 的风险相关，而母亲年龄则不相关。
这是一项基于人群的队列研究，研究对象为 1973 年至 1980 年期间在瑞典出生且在 16 岁时仍居住在瑞典的个体。研究结局为首次因 BPAD 住院。使用 Cox 比例风险回归计算危险比（HR）。
在调整所有潜在混杂变量（除了母亲年龄）后，父亲年龄每增加 10 岁，患 BPAD 的风险 HR 为 1.28（95%置信区间 [CI] 1.11-1.48），但在调整母亲年龄后，这一比值降至 1.20（95% CI 0.97-1.48）。对于母亲年龄与 BPAD 风险之间的关系也得到了类似的结果[在调整父亲年龄之前，HR 为 1.30（95% CI 1.08-1.56），在调整后，HR 为 1.12（95% CI 0.86-1.45）]。如果父母双方的年龄都在 30 岁或以上，则与父母一方或双方年龄在 30 岁或以上相关的 HR 为 1.26（95% CI 1.01-1.57），如果父母双方的年龄都在 30 岁以上，则 HR 为 1.45（95% CI 1.16-1.81）。
与精神分裂症不同，BPAD 的风险似乎与父亲和母亲的年龄都相关。
