FCP：蛋白质组在结构方面的功能覆盖度
FCP: functional coverage of the proteome by structures.
作者信息
García-Serna Ricard, Opatowski Lulla, Mestres Jordi
机构信息
Chemogenomics Laboratory, Research Unit on Biomedical Informatics, Institut Municipal d'Investigació Mèdica and Universitat Pompeu Fabra, Dr Aiguader 88, 08003 Barcelona, Catalonia, Spain.
出版信息
Bioinformatics. 2006 Jul 15;22(14):1792-3. doi: 10.1093/bioinformatics/btl188. Epub 2006 May 16.
MOTIVATION
Tools and resources for translating the remarkable growth witnessed in recent years in the number of protein structures determined experimentally into actual gain in the functional coverage of the proteome are becoming increasingly necessary. We introduce FCP, a publicly accessible web tool dedicated to analyzing the current state and trends of the population of structures within protein families. FCP offers both graphical and quantitative data on the degree of functional coverage of enzymes and nuclear receptors by existing structures, as well as on the bias observed in the distribution of structures along their respective functional classification schemes.
AVAILABILITY
CONTACT
动机
近年来，将通过实验确定的蛋白质结构数量的显著增长转化为蛋白质组功能覆盖范围的实际增加的工具和资源变得越来越必要。我们引入了FCP，这是一个可公开访问的网络工具，专门用于分析蛋白质家族中结构群体的当前状态和趋势。FCP提供了关于现有结构对酶和核受体的功能覆盖程度的图形和定量数据，以及在结构沿着各自功能分类方案分布中观察到的偏差。
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